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A chemical probe based on the PreQ(1) metabolite enables transcriptome-wide mapping of binding sites

The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small molecule interactions. Here, we study the PreQ(1) riboswitch system, assessing sixteen diverse PreQ(1)-derived probes for their ability to s...

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Detalles Bibliográficos
Autores principales:	Balaratnam, Sumirtha, Rhodes, Curran, Bume, Desta Doro, Connelly, Colleen, Lai, Christopher C., Kelley, James A., Yazdani, Kamyar, Homan, Philip J., Incarnato, Danny, Numata, Tomoyuki, Schneekloth Jr, John S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494917/ https://www.ncbi.nlm.nih.gov/pubmed/34615874 http://dx.doi.org/10.1038/s41467-021-25973-x

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