NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits NEK7 within hetero-oligomers that nucleate ASC and caspase-1 filaments, but the apical molecular mechanisms underlying inflam...

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Detalles Bibliográficos
Autores principales: Niu, Tingting, De Rosny, Charlotte, Chautard, Séverine, Rey, Amaury, Patoli, Danish, Groslambert, Marine, Cosson, Camille, Lagrange, Brice, Zhang, Zhirong, Visvikis, Orane, Hacot, Sabine, Hologne, Maggy, Walker, Olivier, Wong, Jeimin, Wang, Ping, Ricci, Roméo, Henry, Thomas, Boyer, Laurent, Petrilli, Virginie, Py, Bénédicte F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494922/
https://www.ncbi.nlm.nih.gov/pubmed/34615873
http://dx.doi.org/10.1038/s41467-021-26142-w

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