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Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins

Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) plays a key role in...

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Detalles Bibliográficos
Autores principales:	Lepesheva, Anna, Osickova, Adriana, Holubova, Jana, Jurnecka, David, Knoblochova, Sarka, Espinosa-Vinals, Carlos, Bumba, Ladislav, Skopova, Karolina, Fiser, Radovan, Osicka, Radim, Sebo, Peter, Masin, Jiri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494930/ https://www.ncbi.nlm.nih.gov/pubmed/34615931 http://dx.doi.org/10.1038/s41598-021-99112-3

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