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The oral vaccine based on self-replicating RNA lipid nanoparticles can simultaneously neutralize both SARS-CoV-2 variants alpha and delta

The aim of this study was to evaluate self-replicating RNA lipid nanoparticles (saRNA LNPs) to neutralize SARS-CoV-2 variants delta (B.1.617 lineage) and alpha (B.1.1.7 lineage). Before immunization of mice with saRNA LNPs, we saw high expression of S-protein at both mRNA and protein levels after tr...

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Detalles Bibliográficos
Autores principales:	Mohammadi, Golamabbas, Sotoudehnia Koranni, Zahra, Jebali, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495003/ https://www.ncbi.nlm.nih.gov/pubmed/34655852 http://dx.doi.org/10.1016/j.intimp.2021.108231

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