Structure-guided machine learning prediction of drug resistance mutations in Abelson 1 kinase

Kinases play crucial roles in cellular signalling and biological processes with their dysregulation associated with diseases, including cancers. Kinase inhibitors, most notably those targeting ABeLson 1 (ABL1) kinase in chronic myeloid leukemia, have had a significant impact on cancer survival, yet...

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Detalles Bibliográficos
Autores principales: Zhou, Yunzhuo, Portelli, Stephanie, Pat, Megan, Rodrigues, Carlos H.M., Nguyen, Thanh-Binh, Pires, Douglas E.V., Ascher, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495037/
https://www.ncbi.nlm.nih.gov/pubmed/34667533
http://dx.doi.org/10.1016/j.csbj.2021.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495037/
https://www.ncbi.nlm.nih.gov/pubmed/34667533
http://dx.doi.org/10.1016/j.csbj.2021.09.016

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