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Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study

BACKGROUND: Upadacitinib, a novel selective Janus kinase 1 (JAK1) inhibitor, has been recently approved by the US FDA for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) met...

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Detalles Bibliográficos
Autores principales:	Wang, Meng-Jie, Zhao, Yu-Hang, Fan, Chen, Wang, Ying-Jie, Wang, Xin-Qi, Qiu, Xiang-Jun, Shen, Rui-Le
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495142/ https://www.ncbi.nlm.nih.gov/pubmed/34629864 http://dx.doi.org/10.2147/DDDT.S332282

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