Cargando…

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Markakis, Ioannis, Charitakis, Ioannis, Beeton, Christine, Galani, Melpomeni, Repousi, Elpida, Aggeloglou, Stella, Sfikakis, Petros P., Pennington, Michael W., Chandy, K. George, Poulopoulou, Cornelia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495199/ https://www.ncbi.nlm.nih.gov/pubmed/34630091 http://dx.doi.org/10.3389/fphar.2021.714841

Ejemplares similares

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis
por: Tanner, Mark R., et al.
Publicado: (2019)

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis
por: Wang, Yuqing, et al.
Publicado: (2023)

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels
por: Ong, Seow Theng, et al.
Publicado: (2022)

A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation
por: Rashid, M. Harunur, et al.
Publicado: (2013)

Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK
por: Pennington, Michael W., et al.
Publicado: (2015)

Modulation of Kv Channel Expression and Function by TCR and Costimulatory Signals during Peripheral CD4(+) Lymphocyte Differentiation
por: Liu, Qing-Hua, et al.
Publicado: (2002)

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats
por: Bergmann, Ralf, et al.
Publicado: (2017)

Kv7 and Kv11 channels in myometrial regulation
por: Greenwood, Iain A, et al.
Publicado: (2014)

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases
por: Rashid, M. Harunur, et al.
Publicado: (2014)

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
por: Beeton, Christine, et al.
Publicado: (2007)

Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes
por: Koshy, Shyny, et al.
Publicado: (2013)

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
por: Leanza, Luigi, et al.
Publicado: (2012)

Tamoxifen Inhibition of Kv7.2/Kv7.3 Channels
por: Ferrer, Tania, et al.
Publicado: (2013)

Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure
por: Gialafos, Elias J., et al.
Publicado: (2008)

Clinical Heterogeneity of Guillain-Barré Syndrome in the Emergency Department: Impact on Clinical Outcome
por: Papathanasiou, Athanasios, et al.
Publicado: (2016)

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes
por: Ren, Yunzhao R., et al.
Publicado: (2008)

Physiological Role of Kv1.3 Channel in T Lymphocyte Cell Investigated Quantitatively by Kinetic Modeling
por: Hou, Panpan, et al.
Publicado: (2014)

Mechanosensitive Gating of Kv Channels
por: Morris, Catherine E., et al.
Publicado: (2015)

Klaviersonaten, KV 310, KV 333, KV 545
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1989)

Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels
por: Kazama, Itsuro
Publicado: (2015)

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy
por: Kleinecke, Sandra, et al.
Publicado: (2017)

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders
por: Bocksteins, Elke
Publicado: (2016)

Regulation of K(+) Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
por: Zhang, Yuchen, et al.
Publicado: (2021)

Inhibitory effects of telmisartan on culture and proliferation of and Kv1.3 potassium channel expression in peripheral blood CD4(+) T lymphocytes from Xinjiang Kazakh patients with hypertension
por: Huang, Sha-Sha, et al.
Publicado: (2016)

Constitutive Activation of the Shaker Kv Channel
por: Sukhareva, Manana, et al.
Publicado: (2003)

Kv7 Channels in Lung Diseases
por: Mondejar-Parreño, Gema, et al.
Publicado: (2020)

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels
por: David, Jens-Peter, et al.
Publicado: (2015)

Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice
por: Xu, Xiaoju, et al.
Publicado: (2020)

Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus
por: Khodoun, Marat, et al.
Publicado: (2020)

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer
por: Comes, Núria, et al.
Publicado: (2013)

Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition
por: Hansen, Jan, et al.
Publicado: (2020)

Assessment of the Validity and Reproducibility of a Novel Standardized Test Meal for the Study of Postprandial Triacylglycerol Concentrations
por: Tentolouris, Nikolaos, et al.
Publicado: (2017)

Erratum to: Assessment of the Validity and Reproducibility of a Novel Standardized Test Meal for the Study of Postprandial Triacylglycerol Concentrations
por: Tentolouris, Nikolaos, et al.
Publicado: (2017)

Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients
por: Gonzalo, Hugo, et al.
Publicado: (2019)

Changes in peripheral T-lymphocyte subsets and serum cytokines in patients with systemic sclerosis
por: Guo, Rong-Hong, et al.
Publicado: (2022)

The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels
por: Bocksteins, Elke, et al.
Publicado: (2012)

Peripheral neuropathy in patients with multiple sclerosis
por: Khan, Adnan, et al.
Publicado: (2018)

Expression, Cellular and Subcellular Localisation of Kv4.2 and Kv4.3 Channels in the Rodent Hippocampus
por: Alfaro-Ruíz, Rocío, et al.
Publicado: (2019)

Dynamics of Kv1 Channel Transport in Axons
por: Gu, Yuanzheng, et al.
Publicado: (2010)

The Kv7 Channel and Cardiovascular Risk Factors
por: Fosmo, Andreas L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_62ds0ht3retsebj9r1s0pn1dm9