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Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy

Introduction and Aims: Elevated plasma levels of C-reactive protein (CRP) are closely associated with progressive renal injury in patients with chronic kidney disease (CKD). Here, we tested a hypothesis that CRP may promote renal fibrosis and inflammation via a TGF-β/Smad3-dependent mechanism. Metho...

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Detalles Bibliográficos
Autores principales:	You, Yong-Ke, Wu, Wei-Feng, Huang, Xiao-Ru, Li, Hai-Di, Ren, Ye-Ping, Zeng, Jin-Cheng, Chen, Haiyong, Lan, Hui Yao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495386/ https://www.ncbi.nlm.nih.gov/pubmed/34671208 http://dx.doi.org/10.7150/ijbs.62929

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