The Role of p38γ in Cancer: From review to outlook

p38γ is a member of the p38 Mitogen Activated Protein Kinases (p38 MAPKs). It contains four subtypes in mammalian cells encoded by different genes including p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). Recent studies revealed that p38γ may exhibit a crucial role in tumorigenesis a...

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Detalles Bibliográficos
Autores principales: Xu, Wentao, Liu, Rui, Dai, Ying, Hong, Shaocheng, Dong, Huke, Wang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495394/
https://www.ncbi.nlm.nih.gov/pubmed/34671218
http://dx.doi.org/10.7150/ijbs.63537
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author Xu, Wentao
Liu, Rui
Dai, Ying
Hong, Shaocheng
Dong, Huke
Wang, Hua
author_facet Xu, Wentao
Liu, Rui
Dai, Ying
Hong, Shaocheng
Dong, Huke
Wang, Hua
author_sort Xu, Wentao
collection PubMed
description p38γ is a member of the p38 Mitogen Activated Protein Kinases (p38 MAPKs). It contains four subtypes in mammalian cells encoded by different genes including p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). Recent studies revealed that p38γ may exhibit a crucial role in tumorigenesis and cancer aggressiveness. Despite the large number of published literatures, further researches are demanded to clarify its role in cancer development, the tissue-specific function and associated novel treatment strategies. In this article, we provide the latest view on the connection between p38γ and malignant tumors, highlighting the function of p38γ. The clinical value of p38γ is also discussed, helping the translation into the remarkable therapeutic strategy in tumor diseases.
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spelling pubmed-84953942021-10-19 The Role of p38γ in Cancer: From review to outlook Xu, Wentao Liu, Rui Dai, Ying Hong, Shaocheng Dong, Huke Wang, Hua Int J Biol Sci Review p38γ is a member of the p38 Mitogen Activated Protein Kinases (p38 MAPKs). It contains four subtypes in mammalian cells encoded by different genes including p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). Recent studies revealed that p38γ may exhibit a crucial role in tumorigenesis and cancer aggressiveness. Despite the large number of published literatures, further researches are demanded to clarify its role in cancer development, the tissue-specific function and associated novel treatment strategies. In this article, we provide the latest view on the connection between p38γ and malignant tumors, highlighting the function of p38γ. The clinical value of p38γ is also discussed, helping the translation into the remarkable therapeutic strategy in tumor diseases. Ivyspring International Publisher 2021-09-23 /pmc/articles/PMC8495394/ /pubmed/34671218 http://dx.doi.org/10.7150/ijbs.63537 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Xu, Wentao
Liu, Rui
Dai, Ying
Hong, Shaocheng
Dong, Huke
Wang, Hua
The Role of p38γ in Cancer: From review to outlook
title The Role of p38γ in Cancer: From review to outlook
title_full The Role of p38γ in Cancer: From review to outlook
title_fullStr The Role of p38γ in Cancer: From review to outlook
title_full_unstemmed The Role of p38γ in Cancer: From review to outlook
title_short The Role of p38γ in Cancer: From review to outlook
title_sort role of p38γ in cancer: from review to outlook
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495394/
https://www.ncbi.nlm.nih.gov/pubmed/34671218
http://dx.doi.org/10.7150/ijbs.63537
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