Cargando…

CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association with CDKN2A expression and immune invasion...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Jun-peng, Wang, Jing, Huang, Jin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495430/
https://www.ncbi.nlm.nih.gov/pubmed/34405225
http://dx.doi.org/10.1042/BSR20211103
_version_ 1784579550647156736
author Luo, Jun-peng
Wang, Jing
Huang, Jin-hua
author_facet Luo, Jun-peng
Wang, Jing
Huang, Jin-hua
author_sort Luo, Jun-peng
collection PubMed
description Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association with CDKN2A expression and immune invasion with the risk of developing HCC. A totally of 2207 different genes were found between HCC and adjacent liver tissues from TCGA and GEO databases. CDKN2A was highly expressed in HCC and associated with poorer overall survival and disease-free survival. Notably, CDKN2A expression was positively correlated with infiltrating levels into purity, B cell, CD+8 T cell, CD+4 T cell, macrophage, neutrophil, and dendritic cells in HCC. CDKN2A expression showed strong correlations between diverse immune marker sets in HCC. These findings suggest that CDKN2A expression potentially contributes to regulation of tumor-associated macrophages and can be used as a prognostic biomarker for determining prognosis and immune infiltration in HCC.
format Online
Article
Text
id pubmed-8495430
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-84954302021-10-14 CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma Luo, Jun-peng Wang, Jing Huang, Jin-hua Biosci Rep Bioinformatics Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association with CDKN2A expression and immune invasion with the risk of developing HCC. A totally of 2207 different genes were found between HCC and adjacent liver tissues from TCGA and GEO databases. CDKN2A was highly expressed in HCC and associated with poorer overall survival and disease-free survival. Notably, CDKN2A expression was positively correlated with infiltrating levels into purity, B cell, CD+8 T cell, CD+4 T cell, macrophage, neutrophil, and dendritic cells in HCC. CDKN2A expression showed strong correlations between diverse immune marker sets in HCC. These findings suggest that CDKN2A expression potentially contributes to regulation of tumor-associated macrophages and can be used as a prognostic biomarker for determining prognosis and immune infiltration in HCC. Portland Press Ltd. 2021-10-06 /pmc/articles/PMC8495430/ /pubmed/34405225 http://dx.doi.org/10.1042/BSR20211103 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Bioinformatics
Luo, Jun-peng
Wang, Jing
Huang, Jin-hua
CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title_full CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title_fullStr CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title_full_unstemmed CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title_short CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
title_sort cdkn2a is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495430/
https://www.ncbi.nlm.nih.gov/pubmed/34405225
http://dx.doi.org/10.1042/BSR20211103
work_keys_str_mv AT luojunpeng cdkn2aisaprognosticbiomarkerandcorrelatedwithimmuneinfiltratesinhepatocellularcarcinoma
AT wangjing cdkn2aisaprognosticbiomarkerandcorrelatedwithimmuneinfiltratesinhepatocellularcarcinoma
AT huangjinhua cdkn2aisaprognosticbiomarkerandcorrelatedwithimmuneinfiltratesinhepatocellularcarcinoma