Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis

Jaundice, the clinical hallmark of infection‐associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3‐kinase‐γ (PI3Kγ) are protected against membrane disintegration and hepatic excretory dy...

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Detalles Bibliográficos
Autores principales: Press, Adrian T, Babic, Petra, Hoffmann, Bianca, Müller, Tina, Foo, Wanling, Hauswald, Walter, Benecke, Jovana, Beretta, Martina, Cseresnyés, Zoltán, Hoeppener, Stephanie, Nischang, Ivo, Coldewey, Sina M, Gräler, Markus H, Bauer, Reinhard, Gonnert, Falk, Gaßler, Nikolaus, Wetzker, Reinhard, Figge, Marc Thilo, Schubert, Ulrich S, Bauer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495460/
https://www.ncbi.nlm.nih.gov/pubmed/34472699
http://dx.doi.org/10.15252/emmm.202114436

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