Cargando…

Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is a common type of cancer, with a mortality of >80% worldwide. Gigantol is a bibenzyl compound that displays anticancer activity. The aim of the present study was to determine the biological activity of gigantol in NSCLC and to elucidate the underlying molecula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Yuxing, Hao, Yi, Xu, Hui, Chen, Kai, Ren, Baozhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495587/ https://www.ncbi.nlm.nih.gov/pubmed/34630671 http://dx.doi.org/10.3892/etm.2021.10752

Ejemplares similares

Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
por: Unahabhokha, Thitita, et al.
Publicado: (2016)

Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells
por: Bhummaphan, Narumol, et al.
Publicado: (2015)

MiR-138-5p Inhibits the Proliferation of Gastric Cancer Cells by Targeting DEK
por: Zhang, Wei, et al.
Publicado: (2020)

Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells
por: Yu, Shubin, et al.
Publicado: (2018)

Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells
por: Basque, Audrey, et al.
Publicado: (2021)

Extraction and Analysis of Gigantol from Dendrobium officinale with Response Surface Methodology
por: Zheng, Siyan, et al.
Publicado: (2018)

Crowberry inhibits cell proliferation and migration through a molecular mechanism that includes inhibition of DEK and Akt signaling in cholangiocarcinoma
por: Wang, Xue, et al.
Publicado: (2022)

Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia Cells
por: Tian, Xiaoxue, et al.
Publicado: (2022)

MiR-138-5p Inhibits the Proliferation of Gastric Cancer Cells by Targeting DEK [Retraction]
Publicado: (2023)

Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion
por: Zhou, Qian-Cheng, et al.
Publicado: (2018)

miR-1305 Inhibits The Progression Of Non-Small Cell Lung Cancer By Regulating MDM2
por: Cai, Yuxing, et al.
Publicado: (2019)

DEK promotes HPV positive and negative head and neck cancer cell proliferation
por: Adams, Allie K., et al.
Publicado: (2014)

Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling
por: Zhao, Meili, et al.
Publicado: (2020)

Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway
por: Wu, Shibo, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract
por: Wu, Jie, et al.
Publicado: (2015)

Pyrroline-5-carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non-small cell lung cancer
por: Cai, Feng, et al.
Publicado: (2018)

Mechanisms Underlying Cancer Growth and Apoptosis by DEK Overexpression in Colorectal Cancer
por: Lin, Lijuan, et al.
Publicado: (2014)

Role of the DEK oncogene in the development of squamous cell carcinoma
por: Ishida, Kazuhisa, et al.
Publicado: (2020)

Diprophylline inhibits non-small cell lung cancer A549 cell proliferation and migration, and promotes apoptosis, by downregulating PI3K signaling pathway
por: Zhao, Hong-Ying, et al.
Publicado: (2019)

Promotion of cell proliferation by the proto‐oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization
por: Nakashima, Takayuki, et al.
Publicado: (2017)

UNBS5162 inhibits the proliferation of human A549 non‐small‐cell lung cancer cells by promoting apoptosis
por: Liu, Cuicui, et al.
Publicado: (2017)

Andrographolide inhibits non-small cell lung cancer cell proliferation through the activation of the mitochondrial apoptosis pathway and by reprogramming host glucose metabolism
por: Chen, Zhao, et al.
Publicado: (2021)

Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts
por: Losuwannarak, Nattanan, et al.
Publicado: (2019)

Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells
por: Kim, Nam-Yi, et al.
Publicado: (2020)

RSPH14 regulates the proliferation, cell cycle progression, and apoptosis of non‐small cell lung cancer cells
por: Ma, Ke, et al.
Publicado: (2021)

DEK overexpression is predictive of poor prognosis in esophageal squamous cell carcinoma
por: Yi, Huochun, et al.
Publicado: (2019)

Schizandrin A can inhibit non-small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy
por: Zhu, Linhai, et al.
Publicado: (2021)

Sevoflurane Limits Glioma Progression by Regulating Cell Proliferation, Apoptosis, Migration, and Invasion via miR-218-5p/DEK/β-Catenin Axis in Glioma
por: Qi, Yingying, et al.
Publicado: (2021)

Inhibiting proliferation of gefitinib-resistant, non-small cell lung cancer
por: Sudo, Makoto, et al.
Publicado: (2013)

YRDC is upregulated in non-small cell lung cancer and promotes cell proliferation by decreasing cell apoptosis
por: Shen, Haibo, et al.
Publicado: (2020)

The SAF-box domain of chromatin protein DEK
por: Böhm, Friederike, et al.
Publicado: (2005)

miR-210-3p regulates the proliferation and apoptosis of non-small cell lung cancer cells by targeting SIN3A
por: Ren, Jie, et al.
Publicado: (2019)

A DEK domain-containing protein GhDEK2D mediated Gossypium hirsutum enhanced resistance to Verticillium dahliae
por: Zhou, Jinglong, et al.
Publicado: (2022)

Gambogenic acid inhibits the proliferation of small-cell lung cancer cells by arresting the cell cycle and inducing apoptosis
por: Huang, Tingting, et al.
Publicado: (2019)

Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells
por: Li, Ting, et al.
Publicado: (2016)

MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1
por: Li, Guangshun, et al.
Publicado: (2021)

Etomidate inhibits cell proliferation and induces apoptosis in A549 non-small cell lung cancer cells via downregulating WWP2
por: Li, Deqiang, et al.
Publicado: (2021)

MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7
por: Han, Fei, et al.
Publicado: (2021)

19-Hydroxybufalin inhibits non-small cell lung cancer cell proliferation and promotes cell apoptosis via the Wnt/β-catenin pathway
por: Yu, Wei, et al.
Publicado: (2021)

MicroRNA-16-1 Inhibits Tumor Cell Proliferation and Induces Apoptosis in A549 Non-Small Cell Lung Carcinoma Cells
por: Wang, Weihua, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rcgobe2aniqvsq6hosk7a04rcd