Cubosome Based Ion-Selective Optodes–Toward Tunable Biocompatible Sensors

[Image: see text] We report here on a new generation of optical ion-selective sensors benefiting from cubosomes or hexosomes–nanostructural lipid liquid phase. Cubosome as well as hexosome optodes offer biocompatibility, self-assembly preparation, high stability in solution, and unique, tunable analytical performance. The temperature trigger reversibly changes the lipid nanoparticle internal structure–changing analyte access to the bulk of the probe and ultimately affecting the response pattern. Thus, cubosome or hexosome optodes are highly promising alternatives to conventional polymeric based optical nanoprobes.