Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group

[Image: see text] Palladium-catalyzed C(sp(2))–H arylation of ortho C–H bonds involving 2-(1-methylhydrazinyl)pyridine (MHP) as the directing group has been investigated. The reaction proceeds smoothly under an air atmosphere to generate biaryl derivatives in an environmentally friendly manner while...

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Detalles Bibliográficos
Autores principales: Wei, Jian, Shao, Xiaoru, Zhao, Hua, Yang, Hongjian, Qiu, Shuxian, Zhai, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495716/
https://www.ncbi.nlm.nih.gov/pubmed/34632174
http://dx.doi.org/10.1021/acsomega.1c02481
Descripción
Sumario:[Image: see text] Palladium-catalyzed C(sp(2))–H arylation of ortho C–H bonds involving 2-(1-methylhydrazinyl)pyridine (MHP) as the directing group has been investigated. The reaction proceeds smoothly under an air atmosphere to generate biaryl derivatives in an environmentally friendly manner while tolerating a wide range of functional groups. Notably, the directing group present in the product could be easily removed under mild reductive conditions.

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