Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group

[Image: see text] Palladium-catalyzed C(sp(2))–H arylation of ortho C–H bonds involving 2-(1-methylhydrazinyl)pyridine (MHP) as the directing group has been investigated. The reaction proceeds smoothly under an air atmosphere to generate biaryl derivatives in an environmentally friendly manner while...

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Autores principales: Wei, Jian, Shao, Xiaoru, Zhao, Hua, Yang, Hongjian, Qiu, Shuxian, Zhai, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495716/
https://www.ncbi.nlm.nih.gov/pubmed/34632174
http://dx.doi.org/10.1021/acsomega.1c02481
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author Wei, Jian
Shao, Xiaoru
Zhao, Hua
Yang, Hongjian
Qiu, Shuxian
Zhai, Hongbin
author_facet Wei, Jian
Shao, Xiaoru
Zhao, Hua
Yang, Hongjian
Qiu, Shuxian
Zhai, Hongbin
author_sort Wei, Jian
collection PubMed
description [Image: see text] Palladium-catalyzed C(sp(2))–H arylation of ortho C–H bonds involving 2-(1-methylhydrazinyl)pyridine (MHP) as the directing group has been investigated. The reaction proceeds smoothly under an air atmosphere to generate biaryl derivatives in an environmentally friendly manner while tolerating a wide range of functional groups. Notably, the directing group present in the product could be easily removed under mild reductive conditions.
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spelling pubmed-84957162021-10-08 Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group Wei, Jian Shao, Xiaoru Zhao, Hua Yang, Hongjian Qiu, Shuxian Zhai, Hongbin ACS Omega [Image: see text] Palladium-catalyzed C(sp(2))–H arylation of ortho C–H bonds involving 2-(1-methylhydrazinyl)pyridine (MHP) as the directing group has been investigated. The reaction proceeds smoothly under an air atmosphere to generate biaryl derivatives in an environmentally friendly manner while tolerating a wide range of functional groups. Notably, the directing group present in the product could be easily removed under mild reductive conditions. American Chemical Society 2021-09-27 /pmc/articles/PMC8495716/ /pubmed/34632174 http://dx.doi.org/10.1021/acsomega.1c02481 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Wei, Jian
Shao, Xiaoru
Zhao, Hua
Yang, Hongjian
Qiu, Shuxian
Zhai, Hongbin
Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title_full Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title_fullStr Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title_full_unstemmed Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title_short Palladium-Catalyzed Arylation of C(sp(2))–H Bonds with 2-(1-Methylhydrazinyl)pyridine as the Bidentate Directing Group
title_sort palladium-catalyzed arylation of c(sp(2))–h bonds with 2-(1-methylhydrazinyl)pyridine as the bidentate directing group
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495716/
https://www.ncbi.nlm.nih.gov/pubmed/34632174
http://dx.doi.org/10.1021/acsomega.1c02481
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