Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase

[Image: see text] α-Glucosyl triazoles have rarely been tested as α-glucosidase inhibitors, partly due to inefficient synthesis of their precursor α-d-glucosylazide (αGA1). Glycosynthase enzymes, made by nucleophile mutations of retaining β-glucosidases, produce αGA1 in chemical rescue experiments....

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Detalles Bibliográficos
Autores principales: Gorantla, Jaggaiah N., Maniganda, Santhi, Pengthaisong, Salila, Ngiwsara, Lukana, Sawangareetrakul, Phannee, Chokchaisiri, Suwadee, Kittakoop, Prasat, Svasti, Jisnuson, Ketudat Cairns, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495876/
https://www.ncbi.nlm.nih.gov/pubmed/34632227
http://dx.doi.org/10.1021/acsomega.1c03928

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