Cargando…

Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age

[Image: see text] Studies have highlighted the increasing fraction of unidentified organofluorine (UOF) compounds in human blood, whose health effects are not known. In this study, 130 whole blood samples from the Swedish general population were analyzed for extractable organofluorine (EOF) and sele...

Descripción completa

Detalles Bibliográficos
Autores principales: Aro, Rudolf, Eriksson, Ulrika, Kärrman, Anna, Yeung, Leo W. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495894/
https://www.ncbi.nlm.nih.gov/pubmed/34520171
http://dx.doi.org/10.1021/acs.est.1c04031
_version_ 1784579644162310144
author Aro, Rudolf
Eriksson, Ulrika
Kärrman, Anna
Yeung, Leo W. Y.
author_facet Aro, Rudolf
Eriksson, Ulrika
Kärrman, Anna
Yeung, Leo W. Y.
author_sort Aro, Rudolf
collection PubMed
description [Image: see text] Studies have highlighted the increasing fraction of unidentified organofluorine (UOF) compounds in human blood, whose health effects are not known. In this study, 130 whole blood samples from the Swedish general population were analyzed for extractable organofluorine (EOF) and selected per- and polyfluoroalkyl substances (PFAS). Organofluorine mass balance analysis revealed that 60% (0–99%) of the EOF in female samples could not be explained by the 63 monitored PFAS; in males, 41% (0–93%) of the EOF was of unidentified origin. Significant differences between both age groups and gender were seen, with the highest fraction of UOF in young females (70% UOF, aged 18–44), which is contrary to what has been reported in the literature for commonly monitored compounds (e.g., perfluorooctane sulfonic acid, PFOS). Increasing the number of monitored PFAS did not lead to a large decrease of the UOF fraction; the seven highest PFAS (C8–C11 PFCAs, C6–C8 PFSAs) accounted for 98% of sum 63 PFAS. The high fraction of UOF in human samples is of concern, as the chemical species of these organofluorine compounds remain unknown and thus their potential health risks cannot be assessed.
format Online
Article
Text
id pubmed-8495894
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-84958942021-10-08 Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age Aro, Rudolf Eriksson, Ulrika Kärrman, Anna Yeung, Leo W. Y. Environ Sci Technol [Image: see text] Studies have highlighted the increasing fraction of unidentified organofluorine (UOF) compounds in human blood, whose health effects are not known. In this study, 130 whole blood samples from the Swedish general population were analyzed for extractable organofluorine (EOF) and selected per- and polyfluoroalkyl substances (PFAS). Organofluorine mass balance analysis revealed that 60% (0–99%) of the EOF in female samples could not be explained by the 63 monitored PFAS; in males, 41% (0–93%) of the EOF was of unidentified origin. Significant differences between both age groups and gender were seen, with the highest fraction of UOF in young females (70% UOF, aged 18–44), which is contrary to what has been reported in the literature for commonly monitored compounds (e.g., perfluorooctane sulfonic acid, PFOS). Increasing the number of monitored PFAS did not lead to a large decrease of the UOF fraction; the seven highest PFAS (C8–C11 PFCAs, C6–C8 PFSAs) accounted for 98% of sum 63 PFAS. The high fraction of UOF in human samples is of concern, as the chemical species of these organofluorine compounds remain unknown and thus their potential health risks cannot be assessed. American Chemical Society 2021-09-14 2021-10-05 /pmc/articles/PMC8495894/ /pubmed/34520171 http://dx.doi.org/10.1021/acs.est.1c04031 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Aro, Rudolf
Eriksson, Ulrika
Kärrman, Anna
Yeung, Leo W. Y.
Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title_full Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title_fullStr Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title_full_unstemmed Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title_short Organofluorine Mass Balance Analysis of Whole Blood Samples in Relation to Gender and Age
title_sort organofluorine mass balance analysis of whole blood samples in relation to gender and age
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495894/
https://www.ncbi.nlm.nih.gov/pubmed/34520171
http://dx.doi.org/10.1021/acs.est.1c04031
work_keys_str_mv AT arorudolf organofluorinemassbalanceanalysisofwholebloodsamplesinrelationtogenderandage
AT erikssonulrika organofluorinemassbalanceanalysisofwholebloodsamplesinrelationtogenderandage
AT karrmananna organofluorinemassbalanceanalysisofwholebloodsamplesinrelationtogenderandage
AT yeungleowy organofluorinemassbalanceanalysisofwholebloodsamplesinrelationtogenderandage