Fe-S coordination defects in the replicative DNA polymerase delta cause deleterious DNA replication in vivo and subsequent DNA damage in the yeast Saccharomyces cerevisiae

B-type eukaryotic polymerases contain a [4Fe-4S] cluster in their C-terminus domain, whose role is not fully understood yet. Among them, DNA polymerase delta (Polδ) plays an essential role in chromosomal DNA replication, mostly during lagging strand synthesis. Previous in vitro work suggested that t...

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Detalles Bibliográficos
Autores principales: Chanet, Roland, Baïlle, Dorothée, Golinelli-Cohen, Marie-Pierre, Riquier, Sylvie, Guittet, Olivier, Lepoivre, Michel, Huang, Meng-Er, Vernis, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495945/
https://www.ncbi.nlm.nih.gov/pubmed/34009341
http://dx.doi.org/10.1093/g3journal/jkab124

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