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Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)
A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein–protein interactions (PPIs) is described.
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495968/ https://www.ncbi.nlm.nih.gov/pubmed/34704051 http://dx.doi.org/10.1039/d1cb00137j |
| _version_ | 1784579661521485824 |
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| author | Hetherington, Kristina Dutt, Som Ibarra, Amaurys A. Cawood, Emma E. Hobor, Fruzsina Woolfson, Derek N. Edwards, Thomas A. Nelson, Adam Sessions, Richard B. Wilson, Andrew J. |
| author_facet | Hetherington, Kristina Dutt, Som Ibarra, Amaurys A. Cawood, Emma E. Hobor, Fruzsina Woolfson, Derek N. Edwards, Thomas A. Nelson, Adam Sessions, Richard B. Wilson, Andrew J. |
| author_sort | Hetherington, Kristina |
| collection | PubMed |
| description | A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein–protein interactions (PPIs) is described. |
| format | Online Article Text |
| id | pubmed-8495968 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | RSC |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84959682021-10-25 Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) Hetherington, Kristina Dutt, Som Ibarra, Amaurys A. Cawood, Emma E. Hobor, Fruzsina Woolfson, Derek N. Edwards, Thomas A. Nelson, Adam Sessions, Richard B. Wilson, Andrew J. RSC Chem Biol Chemistry A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein–protein interactions (PPIs) is described. RSC 2021-08-16 /pmc/articles/PMC8495968/ /pubmed/34704051 http://dx.doi.org/10.1039/d1cb00137j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | Chemistry Hetherington, Kristina Dutt, Som Ibarra, Amaurys A. Cawood, Emma E. Hobor, Fruzsina Woolfson, Derek N. Edwards, Thomas A. Nelson, Adam Sessions, Richard B. Wilson, Andrew J. Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title | Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title_full | Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title_fullStr | Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title_full_unstemmed | Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title_short | Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS) |
| title_sort | towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (presavs) |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495968/ https://www.ncbi.nlm.nih.gov/pubmed/34704051 http://dx.doi.org/10.1039/d1cb00137j |
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