Cargando…

Computational design and experimental characterization of a photo-controlled mRNA-cap guanine-N7 methyltransferase

The spatial and temporal control of gene expression at the post-transcriptional level is essential in eukaryotic cells and developing multicellular organisms. In recent years optochemical and optogenetic tools have enabled the manipulation and investigation of many steps in the involved processes. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reichert, Dennis, Schepers, Helena, Simke, Julian, Lechner, Horst, Dörner, Wolfgang, Höcker, Birte, Ravoo, Bart Jan, Rentmeister, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495969/ https://www.ncbi.nlm.nih.gov/pubmed/34704053 http://dx.doi.org/10.1039/d1cb00109d

Ejemplares similares

Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1
por: Reichert, Dennis, et al.
Publicado: (2021)

Quantification of mRNA cap-modifications by means of LC-QqQ-MS
por: Muthmann, Nils, et al.
Publicado: (2022)

Synthetic mRNA capping
por: Muttach, Fabian, et al.
Publicado: (2017)

Practical Synthesis of Cap‐4 RNA
por: Leiter, Josef, et al.
Publicado: (2019)

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase
por: Kasprzyk, Renata, et al.
Publicado: (2021)

mRNA Cap-1 Methyltransferase in the SARS Genome
por: von Grotthuss, Marcin, et al.
Publicado: (2003)

Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe
por: Hausmann, Stéphane, et al.
Publicado: (2007)

Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase
por: Sun, Ying, et al.
Publicado: (2014)

Tag‐Free Internal RNA Labeling and Photocaging Based on mRNA Methyltransferases
por: Ovcharenko, Anna, et al.
Publicado: (2020)

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase
por: Cowling, Victoria H.
Publicado: (2019)

A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
por: Shannon, Ashleigh, et al.
Publicado: (2022)

Acid-catalysed liquid-to-solid transitioning of arylazoisoxazole photoswitches
por: Kortekaas, Luuk, et al.
Publicado: (2021)

Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA
por: van Dülmen, Melissa, et al.
Publicado: (2021)

Ribosomal RNA guanine-(N2)-methyltransferases and their targets
por: Sergiev, Petr V., et al.
Publicado: (2007)

A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae
por: Ferron, François, et al.
Publicado: (2019)

Self‐Assembled Cationic Polypeptide Supramolecular Nanogels for Intracellular DNA Delivery
por: Pottanam Chali, Sharafudheen, et al.
Publicado: (2021)

Photocaged 5′ cap analogues for optical control of mRNA translation in cells
por: Klöcker, Nils, et al.
Publicado: (2022)

Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
por: Ahmed-Belkacem, Rostom, et al.
Publicado: (2020)

A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation
por: Muttach, F., et al.
Publicado: (2017)

Post-synthetic benzylation of the mRNA 5′ cap via enzymatic cascade reactions
por: Cornelissen, N. V., et al.
Publicado: (2023)

Correction: A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation
por: Muttach, F., et al.
Publicado: (2017)

Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM
por: Varshney, Dhaval, et al.
Publicado: (2016)

RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs
por: Trotman, Jackson B., et al.
Publicado: (2017)

Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase
por: Hooda, Preeti, et al.
Publicado: (2022)

An Artificial Cofactor Catalyzing the Baylis‐Hillman Reaction with Designed Streptavidin as Protein Host
por: Lechner, Horst, et al.
Publicado: (2021)

mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships
por: Bujnicki, Janusz M, et al.
Publicado: (2001)

Sinefungin resistance of Saccharomyces cerevisiae arising from sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase
por: Zheng, Sushuang, et al.
Publicado: (2007)

mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription
por: Varshney, Dhaval, et al.
Publicado: (2018)

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses
por: Haussmann, Irmgard U., et al.
Publicado: (2022)

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation
por: Smietanski, Miroslaw, et al.
Publicado: (2014)

RNA methyltransferases involved in 5′ cap biosynthesis
por: Byszewska, Magdalena, et al.
Publicado: (2015)

Photo‐responsive Bioactive Surfaces Based on Cucurbit[8]uril‐Mediated Host–Guest Interactions of Arylazopyrazoles
por: Wiemann, Maike, et al.
Publicado: (2017)

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
por: Jin, Xu, et al.
Publicado: (2013)

The mRNA Cap 2′-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes
por: Williams, Graham D., et al.
Publicado: (2020)

Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs
por: Yu, Dan, et al.
Publicado: (2022)

Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells
por: Dunn, Sianadh, et al.
Publicado: (2019)

Development of Improved Mumps Vaccine Candidates by Mutating Viral mRNA Cap Methyltransferase Sites in the Large Polymerase Protein
por: Hao, Xiaoqiang, et al.
Publicado: (2020)

Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate
por: Bobiļeva, Olga, et al.
Publicado: (2021)

Unexpected monolayer-to-bilayer transition of arylazopyrazole surfactants facilitates superior photo-control of fluid interfaces and colloids
por: Honnigfort, Christian, et al.
Publicado: (2020)

UVA-visible photo-excitation of guanine radical cations produces sugar radicals in DNA and model structures
por: Adhikary, Amitava, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_g2tqeuoecdnueq551ipga8vqgc