Mapping and modeling the genomic basis of differential RNA isoform expression at single-cell resolution with LR-Split-seq

The rise in throughput and quality of long-read sequencing should allow unambiguous identification of full-length transcript isoforms. However, its application to single-cell RNA-seq has been limited by throughput and expense. Here we develop and characterize long-read Split-seq (LR-Split-seq), whic...

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Detalles Bibliográficos
Autores principales: Rebboah, Elisabeth, Reese, Fairlie, Williams, Katherine, Balderrama-Gutierrez, Gabriela, McGill, Cassandra, Trout, Diane, Rodriguez, Isaryhia, Liang, Heidi, Wold, Barbara J., Mortazavi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495978/
https://www.ncbi.nlm.nih.gov/pubmed/34620214
http://dx.doi.org/10.1186/s13059-021-02505-w

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