Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

BACKGROUND: The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA. DESIGN: Dunkin-Hartley guinea pigs develop mild primary OA pathology by 5 months o...

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Detalles Bibliográficos
Autores principales: Minton, Dennis M., Elliehausen, Christian J., Javors, Martin A., Santangelo, Kelly S., Konopka, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495984/
https://www.ncbi.nlm.nih.gov/pubmed/34620223
http://dx.doi.org/10.1186/s13075-021-02637-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495984/
https://www.ncbi.nlm.nih.gov/pubmed/34620223
http://dx.doi.org/10.1186/s13075-021-02637-1

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