Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective m...

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Detalles Bibliográficos
Autores principales: Lin, Weifeng, Yang, Zhen, Kaur, Amanpreet, Block, Annika, Vujasinovic, Miroslav, Löhr, J.-Matthias, Globisch, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496035/
https://www.ncbi.nlm.nih.gov/pubmed/34704052
http://dx.doi.org/10.1039/d1cb00132a
Descripción
Sumario:The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.

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