Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN...

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Autores principales: Xu, Biao, Tu, Bo, Chu, Fang, Jalloh, Mohamed, Mu, Jin-Song, Zheng, Jun-Jie, Chen, Wei-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496075/
https://www.ncbi.nlm.nih.gov/pubmed/34615551
http://dx.doi.org/10.1186/s40779-021-00345-0
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author Xu, Biao
Tu, Bo
Chu, Fang
Jalloh, Mohamed
Mu, Jin-Song
Zheng, Jun-Jie
Chen, Wei-Wei
author_facet Xu, Biao
Tu, Bo
Chu, Fang
Jalloh, Mohamed
Mu, Jin-Song
Zheng, Jun-Jie
Chen, Wei-Wei
author_sort Xu, Biao
collection PubMed
description Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00345-0.
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spelling pubmed-84960752021-10-07 Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results Xu, Biao Tu, Bo Chu, Fang Jalloh, Mohamed Mu, Jin-Song Zheng, Jun-Jie Chen, Wei-Wei Mil Med Res Letter to the Editor Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00345-0. BioMed Central 2021-10-07 /pmc/articles/PMC8496075/ /pubmed/34615551 http://dx.doi.org/10.1186/s40779-021-00345-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Xu, Biao
Tu, Bo
Chu, Fang
Jalloh, Mohamed
Mu, Jin-Song
Zheng, Jun-Jie
Chen, Wei-Wei
Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title_full Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title_fullStr Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title_full_unstemmed Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title_short Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
title_sort secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of who product testing with a focus on false-negative results
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496075/
https://www.ncbi.nlm.nih.gov/pubmed/34615551
http://dx.doi.org/10.1186/s40779-021-00345-0
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