Deletion of Sphingosine 1‐Phosphate receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis

Sphingosine 1‐Phosphate receptor 1 (S1P(1), encoded by S1pr1) is a G protein‐coupled receptor that signals in multiple cell types including endothelial cells and cardiomyocytes. Cardiomyocyte‐specific deletion of S1pr1 during mouse development leads to ventricular noncompaction, with 44% of mutant m...

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Detalles Bibliográficos
Autores principales: Jorgensen, Ryan, Katta, Meghna, Wolfe, Jayne, Leach, Desiree F., Lavelle, Bianca, Chun, Jerold, Wilsbacher, Lisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496155/
https://www.ncbi.nlm.nih.gov/pubmed/34618403
http://dx.doi.org/10.14814/phy2.15060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496155/
https://www.ncbi.nlm.nih.gov/pubmed/34618403
http://dx.doi.org/10.14814/phy2.15060

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