Transgenesis of mammalian PABP reveals mRNA polyadenylation as a general stress response mechanism in bacteria

In eukaryotes, mRNA 3′-polyadenylation triggers poly(A) binding protein (PABP) recruitment and stabilization. In a stark contrast, polyadenylation marks mRNAs for degradation in bacteria. To study this difference, we trans-express the mammalian nuclear PABPN1 chromosomally and extra-chromosomally in...

Descripción completa

Detalles Bibliográficos
Autores principales: Francis, Nimmy, Laishram, Rakesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496165/
https://www.ncbi.nlm.nih.gov/pubmed/34646982
http://dx.doi.org/10.1016/j.isci.2021.103119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496165/
https://www.ncbi.nlm.nih.gov/pubmed/34646982
http://dx.doi.org/10.1016/j.isci.2021.103119

Ejemplares similares