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Transgenesis of mammalian PABP reveals mRNA polyadenylation as a general stress response mechanism in bacteria
In eukaryotes, mRNA 3′-polyadenylation triggers poly(A) binding protein (PABP) recruitment and stabilization. In a stark contrast, polyadenylation marks mRNAs for degradation in bacteria. To study this difference, we trans-express the mammalian nuclear PABPN1 chromosomally and extra-chromosomally in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496165/ https://www.ncbi.nlm.nih.gov/pubmed/34646982 http://dx.doi.org/10.1016/j.isci.2021.103119 |