Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeast

Life requires the oligomerization of individual proteins into higher-order assemblies. In order to form functional oligomers, monomers must adopt appropriate 3D structures. Molecular chaperones transiently bind nascent or misfolded proteins to promote proper folding. Single missense mutations freque...

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Detalles Bibliográficos
Autores principales: Denney, Ashley S, Weems, Andrew D, McMurray, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496213/
https://www.ncbi.nlm.nih.gov/pubmed/34544131
http://dx.doi.org/10.1093/g3journal/jkab230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496213/
https://www.ncbi.nlm.nih.gov/pubmed/34544131
http://dx.doi.org/10.1093/g3journal/jkab230

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