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Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels
Despite being one of the most consumed vegetables in the United States, the elemental profile of sweet corn (Zea mays L.) is limited in its dietary contributions. To address this through genetic improvement, a genome-wide association study was conducted for the concentrations of 15 elements in fresh...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496296/ https://www.ncbi.nlm.nih.gov/pubmed/34849806 http://dx.doi.org/10.1093/g3journal/jkab186 |
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author | Baseggio, Matheus Murray, Matthew Wu, Di Ziegler, Gregory Kaczmar, Nicholas Chamness, James Hamilton, John P Buell, C Robin Vatamaniuk, Olena K Buckler, Edward S Smith, Margaret E Baxter, Ivan Tracy, William F Gore, Michael A |
author_facet | Baseggio, Matheus Murray, Matthew Wu, Di Ziegler, Gregory Kaczmar, Nicholas Chamness, James Hamilton, John P Buell, C Robin Vatamaniuk, Olena K Buckler, Edward S Smith, Margaret E Baxter, Ivan Tracy, William F Gore, Michael A |
author_sort | Baseggio, Matheus |
collection | PubMed |
description | Despite being one of the most consumed vegetables in the United States, the elemental profile of sweet corn (Zea mays L.) is limited in its dietary contributions. To address this through genetic improvement, a genome-wide association study was conducted for the concentrations of 15 elements in fresh kernels of a sweet corn association panel. In concordance with mapping results from mature maize kernels, we detected a probable pleiotropic association of zinc and iron concentrations with nicotianamine synthase5 (nas5), which purportedly encodes an enzyme involved in synthesis of the metal chelator nicotianamine. In addition, a pervasive association signal was identified for cadmium concentration within a recombination suppressed region on chromosome 2. The likely causal gene underlying this signal was heavy metal ATPase3 (hma3), whose counterpart in rice, OsHMA3, mediates vacuolar sequestration of cadmium and zinc in roots, whereby regulating zinc homeostasis and cadmium accumulation in grains. In our association panel, hma3 associated with cadmium but not zinc accumulation in fresh kernels. This finding implies that selection for low cadmium will not affect zinc levels in fresh kernels. Although less resolved association signals were detected for boron, nickel, and calcium, all 15 elements were shown to have moderate predictive abilities via whole-genome prediction. Collectively, these results help enhance our genomics-assisted breeding efforts centered on improving the elemental profile of fresh sweet corn kernels. |
format | Online Article Text |
id | pubmed-8496296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84962962021-10-07 Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels Baseggio, Matheus Murray, Matthew Wu, Di Ziegler, Gregory Kaczmar, Nicholas Chamness, James Hamilton, John P Buell, C Robin Vatamaniuk, Olena K Buckler, Edward S Smith, Margaret E Baxter, Ivan Tracy, William F Gore, Michael A G3 (Bethesda) Investigation Despite being one of the most consumed vegetables in the United States, the elemental profile of sweet corn (Zea mays L.) is limited in its dietary contributions. To address this through genetic improvement, a genome-wide association study was conducted for the concentrations of 15 elements in fresh kernels of a sweet corn association panel. In concordance with mapping results from mature maize kernels, we detected a probable pleiotropic association of zinc and iron concentrations with nicotianamine synthase5 (nas5), which purportedly encodes an enzyme involved in synthesis of the metal chelator nicotianamine. In addition, a pervasive association signal was identified for cadmium concentration within a recombination suppressed region on chromosome 2. The likely causal gene underlying this signal was heavy metal ATPase3 (hma3), whose counterpart in rice, OsHMA3, mediates vacuolar sequestration of cadmium and zinc in roots, whereby regulating zinc homeostasis and cadmium accumulation in grains. In our association panel, hma3 associated with cadmium but not zinc accumulation in fresh kernels. This finding implies that selection for low cadmium will not affect zinc levels in fresh kernels. Although less resolved association signals were detected for boron, nickel, and calcium, all 15 elements were shown to have moderate predictive abilities via whole-genome prediction. Collectively, these results help enhance our genomics-assisted breeding efforts centered on improving the elemental profile of fresh sweet corn kernels. Oxford University Press 2021-05-28 /pmc/articles/PMC8496296/ /pubmed/34849806 http://dx.doi.org/10.1093/g3journal/jkab186 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Investigation Baseggio, Matheus Murray, Matthew Wu, Di Ziegler, Gregory Kaczmar, Nicholas Chamness, James Hamilton, John P Buell, C Robin Vatamaniuk, Olena K Buckler, Edward S Smith, Margaret E Baxter, Ivan Tracy, William F Gore, Michael A Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title | Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title_full | Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title_fullStr | Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title_full_unstemmed | Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title_short | Genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
title_sort | genome-wide association study suggests an independent genetic basis of zinc and cadmium concentrations in fresh sweet corn kernels |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496296/ https://www.ncbi.nlm.nih.gov/pubmed/34849806 http://dx.doi.org/10.1093/g3journal/jkab186 |
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