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A functional genomic screen in Saccharomyces cerevisiae reveals divergent mechanisms of resistance to different alkylphosphocholine chemotherapeutic agents

The alkylphosphocholine (APC) class of antineoplastic and antiprotozoal drugs, such as edelfosine and miltefosine, are structural mimics of lyso-phosphatidylcholine (lyso-PC), and are inhibitory to the yeast Saccharomyces cerevisiae at low micromolar concentrations. Cytotoxic effects related to inhi...

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Detalles Bibliográficos
Autores principales:	Garcia, Jaquelin M, Schwabe, Michael J, Voelker, Dennis R, Riekhof, Wayne R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Mutant Screen Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496327/ https://www.ncbi.nlm.nih.gov/pubmed/34568930 http://dx.doi.org/10.1093/g3journal/jkab233

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