Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

Little is known about placental drug transfer and fetal pharmacokinetics despite increasing drug use in pregnant women. While physiologically based pharmacokinetic (PBPK) models can help in some cases to shed light on this knowledge gap, adequate parameterization of placental drug transfer remains c...

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Detalles Bibliográficos
Autores principales: Mian, Paola, Nolan, Bridget, van den Anker, John N., van Calsteren, Kristel, Allegaert, Karel, Lakhi, Nisha, Dallmann, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496351/
https://www.ncbi.nlm.nih.gov/pubmed/34631628
http://dx.doi.org/10.3389/fped.2021.733520

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