Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy

BACKGROUND: Targeted thorium-227 conjugates (TTCs) are an emerging class of targeted alpha therapies (TATs). Their unique mode of action (MoA) is the induction of difficult-to-repair clustered DNA double-strand breaks. However, thus far, their effects on the immune system are largely unknown. Here,...

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Detalles Bibliográficos
Autores principales: Lejeune, Pascale, Cruciani, Véronique, Berg-Larsen, Axel, Schlicker, Andreas, Mobergslien, Anne, Bartnitzky, Lisa, Berndt, Sandra, Zitzmann-Kolbe, Sabine, Kamfenkel, Claudia, Stargard, Stefan, Hammer, Stefanie, Jørgensen, Jennifer S, Jackerott, Malene, Nielsen, Carsten H, Schatz, Christoph A, Hennekes, Hartwig, Karlsson, Jenny, Cuthbertson, Alan S, Mumberg, Dominik, Hagemann, Urs B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496392/
https://www.ncbi.nlm.nih.gov/pubmed/34615703
http://dx.doi.org/10.1136/jitc-2021-002387

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