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Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases

As mitochondrial dysfunction has increasingly been implicated in neurological diseases, much of the investigation focuses on the response of the mitochondria. It appears that mitochondria can respond to external stimuli speedy fast, in seconds. Understanding how mitochondria sense the signal and com...

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Autores principales: Liang, Min-Zong, Ke, Ting-Ling, Chen, Linyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496500/
https://www.ncbi.nlm.nih.gov/pubmed/34630036
http://dx.doi.org/10.3389/fnmol.2021.730604
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author Liang, Min-Zong
Ke, Ting-Ling
Chen, Linyi
author_facet Liang, Min-Zong
Ke, Ting-Ling
Chen, Linyi
author_sort Liang, Min-Zong
collection PubMed
description As mitochondrial dysfunction has increasingly been implicated in neurological diseases, much of the investigation focuses on the response of the mitochondria. It appears that mitochondria can respond to external stimuli speedy fast, in seconds. Understanding how mitochondria sense the signal and communicate with cytosolic pathways are keys to understand mitochondrial regulation in diseases or in response to trauma. It was not until recently that a novel mitochondrial protein, phosphoglycerate mutase family member 5 (PGAM5) has emerged to be a new regulator of mitochondrial homeostasis. Although controversial results reveal beneficial as well as detrimental roles of PGAM5 in cancers, these findings also suggest PGAM5 may have diverse regulation on cellular physiology. Roles of PGAM5 in neuronal tissues remain to be uncovered. This review discusses current knowledge of PGAM5 in neurological diseases and provides future perspectives.
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spelling pubmed-84965002021-10-08 Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases Liang, Min-Zong Ke, Ting-Ling Chen, Linyi Front Mol Neurosci Molecular Neuroscience As mitochondrial dysfunction has increasingly been implicated in neurological diseases, much of the investigation focuses on the response of the mitochondria. It appears that mitochondria can respond to external stimuli speedy fast, in seconds. Understanding how mitochondria sense the signal and communicate with cytosolic pathways are keys to understand mitochondrial regulation in diseases or in response to trauma. It was not until recently that a novel mitochondrial protein, phosphoglycerate mutase family member 5 (PGAM5) has emerged to be a new regulator of mitochondrial homeostasis. Although controversial results reveal beneficial as well as detrimental roles of PGAM5 in cancers, these findings also suggest PGAM5 may have diverse regulation on cellular physiology. Roles of PGAM5 in neuronal tissues remain to be uncovered. This review discusses current knowledge of PGAM5 in neurological diseases and provides future perspectives. Frontiers Media S.A. 2021-09-23 /pmc/articles/PMC8496500/ /pubmed/34630036 http://dx.doi.org/10.3389/fnmol.2021.730604 Text en Copyright © 2021 Liang, Ke and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Liang, Min-Zong
Ke, Ting-Ling
Chen, Linyi
Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title_full Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title_fullStr Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title_full_unstemmed Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title_short Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases
title_sort mitochondrial protein pgam5 emerges as a new regulator in neurological diseases
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496500/
https://www.ncbi.nlm.nih.gov/pubmed/34630036
http://dx.doi.org/10.3389/fnmol.2021.730604
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