Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and sensitization to radiation. Preclinical data show that EGFRvIII-expressing glioblastoma may benefit most from chloroquine because of autophagy dependenc...

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Detalles Bibliográficos
Autores principales: Compter, Inge, Eekers, Danielle B. P., Hoeben, Ann, Rouschop, Kasper M. A., Reymen, Bart, Ackermans, Linda, Beckervordersantforth, Jan, Bauer, Noel J. C., Anten, Monique M., Wesseling, Pieter, Postma, Alida A., De Ruysscher, Dirk, Lambin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper - Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496728/
https://www.ncbi.nlm.nih.gov/pubmed/32866424
http://dx.doi.org/10.1080/15548627.2020.1816343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496728/
https://www.ncbi.nlm.nih.gov/pubmed/32866424
http://dx.doi.org/10.1080/15548627.2020.1816343

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