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HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics

BACKGROUND: Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few stu...

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Autores principales: Chen, Ke-Jun, Li, Feng-Zeng, Ye, Qian, Jia, Meng, Fang, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496777/
https://www.ncbi.nlm.nih.gov/pubmed/34618840
http://dx.doi.org/10.1371/journal.pone.0258053
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author Chen, Ke-Jun
Li, Feng-Zeng
Ye, Qian
Jia, Meng
Fang, Sheng
author_facet Chen, Ke-Jun
Li, Feng-Zeng
Ye, Qian
Jia, Meng
Fang, Sheng
author_sort Chen, Ke-Jun
collection PubMed
description BACKGROUND: Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM. METHODS: This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark’s level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical staining and Western blot analysis for HSP105 were performed. Pigmented nevi (n = 20) served as a control. The staining intensity and percentage of stained cells were expressed as a histochemical score (HSCORE). RESULTS: HSP105 was overexpressed in melanoma compared with nevi. Differences in the HSCORE between nevi (HSCORE = 1.05(0.15,1.50)) and CMM (HSCORE = 2.68(1.80,3.60)) were remarkable (P<0.001). Exposed site lesions, recurrent and metastatic lesions, nodular melanoma and lentigo maligna melanoma were closely associated with higher HSP105 expression (P = 0.011, P = 0.001 and P = 0.001, respectively). Moreover, no significant difference was observed in Clark’s level, Breslow thickness, or lesion duration (P>0.05). CONCLUSION: HSP105 is overexpressed in CMM. Higher HSP105 expression in lesions is associated with different clinicopathological variables. HSP105 may be a potential target for the diagnosis, treatment and prognostic prediction of CMM.
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spelling pubmed-84967772021-10-08 HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics Chen, Ke-Jun Li, Feng-Zeng Ye, Qian Jia, Meng Fang, Sheng PLoS One Research Article BACKGROUND: Heat shock proteins can protect against stress-associated cellular challenges, but they can also protect some tumors from human immune system monitoring. Heat shock protein 105 (HSP105/110) is a high molecular weight protein whose expression has been reported in many cancers, but few studies on its role in cutaneous malignant melanoma have been published. In this study, we analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM. METHODS: This retrospective study included 91 patients with CMM. The clinicopathological characteristics of CMM patients, including age, lesion duration, location, pathological classification, Clark’s level, Breslow thickness, metastasis and recurrence, were collected. Immunohistochemical staining and Western blot analysis for HSP105 were performed. Pigmented nevi (n = 20) served as a control. The staining intensity and percentage of stained cells were expressed as a histochemical score (HSCORE). RESULTS: HSP105 was overexpressed in melanoma compared with nevi. Differences in the HSCORE between nevi (HSCORE = 1.05(0.15,1.50)) and CMM (HSCORE = 2.68(1.80,3.60)) were remarkable (P<0.001). Exposed site lesions, recurrent and metastatic lesions, nodular melanoma and lentigo maligna melanoma were closely associated with higher HSP105 expression (P = 0.011, P = 0.001 and P = 0.001, respectively). Moreover, no significant difference was observed in Clark’s level, Breslow thickness, or lesion duration (P>0.05). CONCLUSION: HSP105 is overexpressed in CMM. Higher HSP105 expression in lesions is associated with different clinicopathological variables. HSP105 may be a potential target for the diagnosis, treatment and prognostic prediction of CMM. Public Library of Science 2021-10-07 /pmc/articles/PMC8496777/ /pubmed/34618840 http://dx.doi.org/10.1371/journal.pone.0258053 Text en © 2021 Chen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chen, Ke-Jun
Li, Feng-Zeng
Ye, Qian
Jia, Meng
Fang, Sheng
HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title_full HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title_fullStr HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title_full_unstemmed HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title_short HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics
title_sort hsp105 expression in cutaneous malignant melanoma: correlation with clinicopathological characteristics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496777/
https://www.ncbi.nlm.nih.gov/pubmed/34618840
http://dx.doi.org/10.1371/journal.pone.0258053
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