Global approaches for profiling transcription initiation

Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including...

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Detalles Bibliográficos
Autores principales: Policastro, Robert A., Zentner, Gabriel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496859/
https://www.ncbi.nlm.nih.gov/pubmed/34632443
http://dx.doi.org/10.1016/j.crmeth.2021.100081
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author Policastro, Robert A.
Zentner, Gabriel E.
author_facet Policastro, Robert A.
Zentner, Gabriel E.
author_sort Policastro, Robert A.
collection PubMed
description Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including cancer. In this review, we discuss the breadth of techniques that have been used to globally profile TSSs and the resulting insights into gene regulation, as well as future prospects in this area of inquiry.
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spelling pubmed-84968592021-10-07 Global approaches for profiling transcription initiation Policastro, Robert A. Zentner, Gabriel E. Cell Rep Methods Review Transcription start site (TSS) selection influences transcript stability and translation as well as protein sequence. Alternative TSS usage is pervasive in organismal development, is a major contributor to transcript isoform diversity in humans, and is frequently observed in human diseases including cancer. In this review, we discuss the breadth of techniques that have been used to globally profile TSSs and the resulting insights into gene regulation, as well as future prospects in this area of inquiry. Elsevier 2021-09-16 /pmc/articles/PMC8496859/ /pubmed/34632443 http://dx.doi.org/10.1016/j.crmeth.2021.100081 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Policastro, Robert A.
Zentner, Gabriel E.
Global approaches for profiling transcription initiation
title Global approaches for profiling transcription initiation
title_full Global approaches for profiling transcription initiation
title_fullStr Global approaches for profiling transcription initiation
title_full_unstemmed Global approaches for profiling transcription initiation
title_short Global approaches for profiling transcription initiation
title_sort global approaches for profiling transcription initiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496859/
https://www.ncbi.nlm.nih.gov/pubmed/34632443
http://dx.doi.org/10.1016/j.crmeth.2021.100081
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