Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy

Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult patients. We found pronounced RNA toxicity in the...

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Detalles Bibliográficos
Autores principales: Sicot, Géraldine, Servais, Laurent, Dinca, Diana M., Leroy, Axelle, Prigogine, Cynthia, Medja, Fadia, Braz, Sandra O., Huguet-Lachon, Aline, Chhuon, Cerina, Nicole, Annie, Gueriba, Noëmy, Oliveira, Ruan, Dan, Bernard, Furling, Denis, Swanson, Maurice S., Guerrera, Ida Chiara, Cheron, Guy, Gourdon, Geneviève, Gomes-Pereira, Mário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496958/
https://www.ncbi.nlm.nih.gov/pubmed/28658620
http://dx.doi.org/10.1016/j.celrep.2017.06.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496958/
https://www.ncbi.nlm.nih.gov/pubmed/28658620
http://dx.doi.org/10.1016/j.celrep.2017.06.006

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