Complexed Crystal Structure of Saccharomyces cerevisiae Dihydroorotase with Inhibitor 5-Fluoroorotate Reveals a New Binding Mode

Dihydroorotase (DHOase) possesses a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine. DHOase catalyzes the reversible cyclization of N-carbamoyl aspartate (CA-asp) to dihydroorotate (DHO) in the third step of the pathway for the biosynthesis of pyr...

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Detalles Bibliográficos
Autores principales: Guan, Hong-Hsiang, Huang, Yen-Hua, Lin, En-Shyh, Chen, Chun-Jung, Huang, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497156/
https://www.ncbi.nlm.nih.gov/pubmed/34630544
http://dx.doi.org/10.1155/2021/2572844

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