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Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery

Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardi...

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Autores principales: Stein‐Merlob, Ashley F., Hsu, Jeffrey J., Colton, Bradley, Berg, Christopher J., Ferreira, Allison, Price, Megan M., Wainberg, Zev, Baas, Arnold S., Deng, Mario C., Parikh, Rushi V., Yang, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497199/
https://www.ncbi.nlm.nih.gov/pubmed/34390221
http://dx.doi.org/10.1002/ehf2.13545
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author Stein‐Merlob, Ashley F.
Hsu, Jeffrey J.
Colton, Bradley
Berg, Christopher J.
Ferreira, Allison
Price, Megan M.
Wainberg, Zev
Baas, Arnold S.
Deng, Mario C.
Parikh, Rushi V.
Yang, Eric H.
author_facet Stein‐Merlob, Ashley F.
Hsu, Jeffrey J.
Colton, Bradley
Berg, Christopher J.
Ferreira, Allison
Price, Megan M.
Wainberg, Zev
Baas, Arnold S.
Deng, Mario C.
Parikh, Rushi V.
Yang, Eric H.
author_sort Stein‐Merlob, Ashley F.
collection PubMed
description Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardiogenic shock and ventricular arrhythmias. Treatment of ICI‐associated myocarditis requires aggressive immunosuppression and supportive therapy. In this case, the patient required advanced mechanical circulatory support as a bridge to recovery. This case highlights the complexity of diagnosis, haemodynamic management, and treatment of fulminant ICI myocarditis.
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spelling pubmed-84971992021-10-12 Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery Stein‐Merlob, Ashley F. Hsu, Jeffrey J. Colton, Bradley Berg, Christopher J. Ferreira, Allison Price, Megan M. Wainberg, Zev Baas, Arnold S. Deng, Mario C. Parikh, Rushi V. Yang, Eric H. ESC Heart Fail Case Reports Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardiogenic shock and ventricular arrhythmias. Treatment of ICI‐associated myocarditis requires aggressive immunosuppression and supportive therapy. In this case, the patient required advanced mechanical circulatory support as a bridge to recovery. This case highlights the complexity of diagnosis, haemodynamic management, and treatment of fulminant ICI myocarditis. John Wiley and Sons Inc. 2021-08-13 /pmc/articles/PMC8497199/ /pubmed/34390221 http://dx.doi.org/10.1002/ehf2.13545 Text en © 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Stein‐Merlob, Ashley F.
Hsu, Jeffrey J.
Colton, Bradley
Berg, Christopher J.
Ferreira, Allison
Price, Megan M.
Wainberg, Zev
Baas, Arnold S.
Deng, Mario C.
Parikh, Rushi V.
Yang, Eric H.
Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title_full Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title_fullStr Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title_full_unstemmed Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title_short Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
title_sort keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497199/
https://www.ncbi.nlm.nih.gov/pubmed/34390221
http://dx.doi.org/10.1002/ehf2.13545
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