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Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery
Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497199/ https://www.ncbi.nlm.nih.gov/pubmed/34390221 http://dx.doi.org/10.1002/ehf2.13545 |
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author | Stein‐Merlob, Ashley F. Hsu, Jeffrey J. Colton, Bradley Berg, Christopher J. Ferreira, Allison Price, Megan M. Wainberg, Zev Baas, Arnold S. Deng, Mario C. Parikh, Rushi V. Yang, Eric H. |
author_facet | Stein‐Merlob, Ashley F. Hsu, Jeffrey J. Colton, Bradley Berg, Christopher J. Ferreira, Allison Price, Megan M. Wainberg, Zev Baas, Arnold S. Deng, Mario C. Parikh, Rushi V. Yang, Eric H. |
author_sort | Stein‐Merlob, Ashley F. |
collection | PubMed |
description | Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardiogenic shock and ventricular arrhythmias. Treatment of ICI‐associated myocarditis requires aggressive immunosuppression and supportive therapy. In this case, the patient required advanced mechanical circulatory support as a bridge to recovery. This case highlights the complexity of diagnosis, haemodynamic management, and treatment of fulminant ICI myocarditis. |
format | Online Article Text |
id | pubmed-8497199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84971992021-10-12 Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery Stein‐Merlob, Ashley F. Hsu, Jeffrey J. Colton, Bradley Berg, Christopher J. Ferreira, Allison Price, Megan M. Wainberg, Zev Baas, Arnold S. Deng, Mario C. Parikh, Rushi V. Yang, Eric H. ESC Heart Fail Case Reports Immune checkpoint inhibitor (ICI)‐associated myocarditis is a rare, potentially life‐threatening complication of immunotherapy. We report a case of a 60‐year‐old female with a history of colorectal cancer treated with nivolumab immunotherapy who presented with new cardiomyopathy complicated by cardiogenic shock and ventricular arrhythmias. Treatment of ICI‐associated myocarditis requires aggressive immunosuppression and supportive therapy. In this case, the patient required advanced mechanical circulatory support as a bridge to recovery. This case highlights the complexity of diagnosis, haemodynamic management, and treatment of fulminant ICI myocarditis. John Wiley and Sons Inc. 2021-08-13 /pmc/articles/PMC8497199/ /pubmed/34390221 http://dx.doi.org/10.1002/ehf2.13545 Text en © 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Stein‐Merlob, Ashley F. Hsu, Jeffrey J. Colton, Bradley Berg, Christopher J. Ferreira, Allison Price, Megan M. Wainberg, Zev Baas, Arnold S. Deng, Mario C. Parikh, Rushi V. Yang, Eric H. Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title | Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title_full | Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title_fullStr | Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title_full_unstemmed | Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title_short | Keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
title_sort | keeping immune checkpoint inhibitor myocarditis in check: advanced circulatory mechanical support as a bridge to recovery |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497199/ https://www.ncbi.nlm.nih.gov/pubmed/34390221 http://dx.doi.org/10.1002/ehf2.13545 |
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