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Microbiota-mediated protection against antibiotic-resistant pathogens
Colonization by the microbiota provides one of our most effective barriers against infection by pathogenic microbes. The microbiota protects against infection by priming immune defenses, by metabolic exclusion of pathogens from their preferred niches, and through direct antimicrobial antagonism. Dis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497270/ https://www.ncbi.nlm.nih.gov/pubmed/33947987 http://dx.doi.org/10.1038/s41435-021-00129-5 |
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author | Panwar, Rekha B. Sequeira, Richard P. Clarke, Thomas B. |
author_facet | Panwar, Rekha B. Sequeira, Richard P. Clarke, Thomas B. |
author_sort | Panwar, Rekha B. |
collection | PubMed |
description | Colonization by the microbiota provides one of our most effective barriers against infection by pathogenic microbes. The microbiota protects against infection by priming immune defenses, by metabolic exclusion of pathogens from their preferred niches, and through direct antimicrobial antagonism. Disruption of the microbiota, especially by antibiotics, is a major risk factor for bacterial pathogen colonization. Restoration of the microbiota through microbiota transplantation has been shown to be an effective way to reduce pathogen burden in the intestine but comes with a number of drawbacks, including the possibility of transferring other pathogens into the host, lack of standardization, and potential disruption to host metabolism. More refined methods to exploit the power of the microbiota would allow us to utilize its protective power without the drawbacks of fecal microbiota transplantation. To achieve this requires detailed understanding of which members of the microbiota protect against specific pathogens and the mechanistic basis for their effects. In this review, we will discuss the clinical and experimental evidence that has begun to reveal which members of the microbiota protect against some of the most troublesome antibiotic-resistant pathogens: Klebsiella pneumoniae, vancomycin-resistant enterococci, and Clostridioides difficile. |
format | Online Article Text |
id | pubmed-8497270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84972702021-10-11 Microbiota-mediated protection against antibiotic-resistant pathogens Panwar, Rekha B. Sequeira, Richard P. Clarke, Thomas B. Genes Immun Review Article Colonization by the microbiota provides one of our most effective barriers against infection by pathogenic microbes. The microbiota protects against infection by priming immune defenses, by metabolic exclusion of pathogens from their preferred niches, and through direct antimicrobial antagonism. Disruption of the microbiota, especially by antibiotics, is a major risk factor for bacterial pathogen colonization. Restoration of the microbiota through microbiota transplantation has been shown to be an effective way to reduce pathogen burden in the intestine but comes with a number of drawbacks, including the possibility of transferring other pathogens into the host, lack of standardization, and potential disruption to host metabolism. More refined methods to exploit the power of the microbiota would allow us to utilize its protective power without the drawbacks of fecal microbiota transplantation. To achieve this requires detailed understanding of which members of the microbiota protect against specific pathogens and the mechanistic basis for their effects. In this review, we will discuss the clinical and experimental evidence that has begun to reveal which members of the microbiota protect against some of the most troublesome antibiotic-resistant pathogens: Klebsiella pneumoniae, vancomycin-resistant enterococci, and Clostridioides difficile. Nature Publishing Group UK 2021-05-04 2021 /pmc/articles/PMC8497270/ /pubmed/33947987 http://dx.doi.org/10.1038/s41435-021-00129-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Panwar, Rekha B. Sequeira, Richard P. Clarke, Thomas B. Microbiota-mediated protection against antibiotic-resistant pathogens |
title | Microbiota-mediated protection against antibiotic-resistant pathogens |
title_full | Microbiota-mediated protection against antibiotic-resistant pathogens |
title_fullStr | Microbiota-mediated protection against antibiotic-resistant pathogens |
title_full_unstemmed | Microbiota-mediated protection against antibiotic-resistant pathogens |
title_short | Microbiota-mediated protection against antibiotic-resistant pathogens |
title_sort | microbiota-mediated protection against antibiotic-resistant pathogens |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497270/ https://www.ncbi.nlm.nih.gov/pubmed/33947987 http://dx.doi.org/10.1038/s41435-021-00129-5 |
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