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Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome

Hyperadrenergic orthostatic hypertension (hyper OH), defined as OH with elevated levels of upright plasma norepinephrine (NE), is assumed to be a clinical expression of peripheral sympathetic denervation (PSD). Primary Sjogren’s syndrome (pSS) is an autoimmune disease that not only affects the exocr...

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Autores principales: Takahashi, Junichiro, Umehara, Tadashi, Mitsumura, Hidetaka, Murakami, Hidetomo, Iguchi, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497279/
https://www.ncbi.nlm.nih.gov/pubmed/34660015
http://dx.doi.org/10.7759/cureus.17805
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author Takahashi, Junichiro
Umehara, Tadashi
Mitsumura, Hidetaka
Murakami, Hidetomo
Iguchi, Yasuyuki
author_facet Takahashi, Junichiro
Umehara, Tadashi
Mitsumura, Hidetaka
Murakami, Hidetomo
Iguchi, Yasuyuki
author_sort Takahashi, Junichiro
collection PubMed
description Hyperadrenergic orthostatic hypertension (hyper OH), defined as OH with elevated levels of upright plasma norepinephrine (NE), is assumed to be a clinical expression of peripheral sympathetic denervation (PSD). Primary Sjogren’s syndrome (pSS) is an autoimmune disease that not only affects the exocrine glands but also develops autonomic neuropathy with PSD. We present a hyper OH with PSD possibly associated with pSS and successfully treated with intravenous immunoglobulin (IVIg). The case was a 60-year-old man who developed recurrent syncope on rapid standing from a sitting position. Head-up tilt test and NE infusion test showed hyper OH with PSD. This case report raises the possible associations between hyper OH and autonomic neuropathy as pSS developed.
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spelling pubmed-84972792021-10-14 Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome Takahashi, Junichiro Umehara, Tadashi Mitsumura, Hidetaka Murakami, Hidetomo Iguchi, Yasuyuki Cureus Neurology Hyperadrenergic orthostatic hypertension (hyper OH), defined as OH with elevated levels of upright plasma norepinephrine (NE), is assumed to be a clinical expression of peripheral sympathetic denervation (PSD). Primary Sjogren’s syndrome (pSS) is an autoimmune disease that not only affects the exocrine glands but also develops autonomic neuropathy with PSD. We present a hyper OH with PSD possibly associated with pSS and successfully treated with intravenous immunoglobulin (IVIg). The case was a 60-year-old man who developed recurrent syncope on rapid standing from a sitting position. Head-up tilt test and NE infusion test showed hyper OH with PSD. This case report raises the possible associations between hyper OH and autonomic neuropathy as pSS developed. Cureus 2021-09-07 /pmc/articles/PMC8497279/ /pubmed/34660015 http://dx.doi.org/10.7759/cureus.17805 Text en Copyright © 2021, Takahashi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Takahashi, Junichiro
Umehara, Tadashi
Mitsumura, Hidetaka
Murakami, Hidetomo
Iguchi, Yasuyuki
Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title_full Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title_fullStr Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title_full_unstemmed Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title_short Hyperadrenergic Orthostatic Hypotension With Pure Peripheral Sympathetic Denervation Associated With Sjogren’s Syndrome
title_sort hyperadrenergic orthostatic hypotension with pure peripheral sympathetic denervation associated with sjogren’s syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497279/
https://www.ncbi.nlm.nih.gov/pubmed/34660015
http://dx.doi.org/10.7759/cureus.17805
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