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Detection of Isopeptide Bonds in Monoclonal Antibody Aggregates

PURPOSE: A major difficulty in monoclonal antibody (mAb) therapeutic development is product aggregation. In this study, intermolecular isopeptide bonds in mAb aggregates were characterized for the first time. We aim to propose a mechanism of covalent aggregation in a model antibody using stressed st...

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Detalles Bibliográficos
Autores principales:	Powell, Thomas, Knight, Michael J., Wood, Amanda, O’Hara, John, Burkitt, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497302/ https://www.ncbi.nlm.nih.gov/pubmed/34528168 http://dx.doi.org/10.1007/s11095-021-03103-y

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