Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits any survival benefits conferred by the drug. Here we show that the convection-enhanced delivery of nanoparticles containing disulfide bonds (which are cleaved in the reductive environment of the tumour) and e...

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Detalles Bibliográficos
Autores principales: Wang, Yongheng, Jiang, Yuhang, Wei, Dengshuai, Singh, Priya, Yu, Yingjie, Lee, Teresa, Zhang, Lingpu, Mandl, Hanna K., Piotrowski-Daspit, Alexandra S., Chen, Xinyuan, Li, Fan, Li, Xing, Cheng, Yiyu, Josowitz, Alexander, Yang, Fan, Zhao, Yao, Wang, Fuyi, Zhao, Zhenwen, Huttner, Anita, Bindra, Ranjit S., Xiao, Haihua, Saltzman, W. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497438/
https://www.ncbi.nlm.nih.gov/pubmed/34045730
http://dx.doi.org/10.1038/s41551-021-00728-7

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