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Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration

Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusin...

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Autores principales: Hirai, Hiromasa, Yamashita, Mariko, Matsumoto, Masanori, Hayakawa, Masaki, Sakai, Kazuya, Ueda, Tetsuo, Ogata, Nahoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497477/
https://www.ncbi.nlm.nih.gov/pubmed/34620972
http://dx.doi.org/10.1038/s41598-021-99557-6
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author Hirai, Hiromasa
Yamashita, Mariko
Matsumoto, Masanori
Hayakawa, Masaki
Sakai, Kazuya
Ueda, Tetsuo
Ogata, Nahoko
author_facet Hirai, Hiromasa
Yamashita, Mariko
Matsumoto, Masanori
Hayakawa, Masaki
Sakai, Kazuya
Ueda, Tetsuo
Ogata, Nahoko
author_sort Hirai, Hiromasa
collection PubMed
description Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.
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spelling pubmed-84974772021-10-08 Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration Hirai, Hiromasa Yamashita, Mariko Matsumoto, Masanori Hayakawa, Masaki Sakai, Kazuya Ueda, Tetsuo Ogata, Nahoko Sci Rep Article Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD. Nature Publishing Group UK 2021-10-07 /pmc/articles/PMC8497477/ /pubmed/34620972 http://dx.doi.org/10.1038/s41598-021-99557-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hirai, Hiromasa
Yamashita, Mariko
Matsumoto, Masanori
Hayakawa, Masaki
Sakai, Kazuya
Ueda, Tetsuo
Ogata, Nahoko
Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_full Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_fullStr Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_full_unstemmed Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_short Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_sort analysis focusing on plasma von willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497477/
https://www.ncbi.nlm.nih.gov/pubmed/34620972
http://dx.doi.org/10.1038/s41598-021-99557-6
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