ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7

Mostrar otras versiones (1)

We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9...

Descripción completa

Detalles Bibliográficos
Autores principales: Fischer, Robert J., van Doremalen, Neeltje, Adney, Danielle R., Yinda, Claude Kwe, Port, Julia R., Holbrook, Myndi G., Schulz, Jonathan E., Williamson, Brandi N., Thomas, Tina, Barbian, Kent, Anzick, Sarah L., Ricklefs, Stacy, Smith, Brian J., Long, Dan, Martens, Craig, Saturday, Greg, de Wit, Emmie, Gilbert, Sarah C., Lambe, Teresa, Munster, Vincent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497486/
https://www.ncbi.nlm.nih.gov/pubmed/34620866
http://dx.doi.org/10.1038/s41467-021-26178-y
_version_ 1784579962804633600
author Fischer, Robert J.
van Doremalen, Neeltje
Adney, Danielle R.
Yinda, Claude Kwe
Port, Julia R.
Holbrook, Myndi G.
Schulz, Jonathan E.
Williamson, Brandi N.
Thomas, Tina
Barbian, Kent
Anzick, Sarah L.
Ricklefs, Stacy
Smith, Brian J.
Long, Dan
Martens, Craig
Saturday, Greg
de Wit, Emmie
Gilbert, Sarah C.
Lambe, Teresa
Munster, Vincent J.
author_facet Fischer, Robert J.
van Doremalen, Neeltje
Adney, Danielle R.
Yinda, Claude Kwe
Port, Julia R.
Holbrook, Myndi G.
Schulz, Jonathan E.
Williamson, Brandi N.
Thomas, Tina
Barbian, Kent
Anzick, Sarah L.
Ricklefs, Stacy
Smith, Brian J.
Long, Dan
Martens, Craig
Saturday, Greg
de Wit, Emmie
Gilbert, Sarah C.
Lambe, Teresa
Munster, Vincent J.
author_sort Fischer, Robert J.
collection PubMed
description We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs.
format Online
Article
Text
id pubmed-8497486
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-84974862021-10-22 ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 Fischer, Robert J. van Doremalen, Neeltje Adney, Danielle R. Yinda, Claude Kwe Port, Julia R. Holbrook, Myndi G. Schulz, Jonathan E. Williamson, Brandi N. Thomas, Tina Barbian, Kent Anzick, Sarah L. Ricklefs, Stacy Smith, Brian J. Long, Dan Martens, Craig Saturday, Greg de Wit, Emmie Gilbert, Sarah C. Lambe, Teresa Munster, Vincent J. Nat Commun Article We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs. Nature Publishing Group UK 2021-10-07 /pmc/articles/PMC8497486/ /pubmed/34620866 http://dx.doi.org/10.1038/s41467-021-26178-y Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Fischer, Robert J.
van Doremalen, Neeltje
Adney, Danielle R.
Yinda, Claude Kwe
Port, Julia R.
Holbrook, Myndi G.
Schulz, Jonathan E.
Williamson, Brandi N.
Thomas, Tina
Barbian, Kent
Anzick, Sarah L.
Ricklefs, Stacy
Smith, Brian J.
Long, Dan
Martens, Craig
Saturday, Greg
de Wit, Emmie
Gilbert, Sarah C.
Lambe, Teresa
Munster, Vincent J.
ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title_full ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title_fullStr ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title_full_unstemmed ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title_short ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7
title_sort chadox1 ncov-19 (azd1222) protects syrian hamsters against sars-cov-2 b.1.351 and b.1.1.7
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497486/
https://www.ncbi.nlm.nih.gov/pubmed/34620866
http://dx.doi.org/10.1038/s41467-021-26178-y
work_keys_str_mv AT fischerrobertj chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT vandoremalenneeltje chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT adneydanieller chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT yindaclaudekwe chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT portjuliar chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT holbrookmyndig chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT schulzjonathane chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT williamsonbrandin chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT thomastina chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT barbiankent chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT anzicksarahl chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT ricklefsstacy chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT smithbrianj chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT longdan chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT martenscraig chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT saturdaygreg chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT dewitemmie chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT gilbertsarahc chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT lambeteresa chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117
AT munstervincentj chadox1ncov19azd1222protectssyrianhamstersagainstsarscov2b1351andb117

Ejemplares similares