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Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer
In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chit...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497614/ https://www.ncbi.nlm.nih.gov/pubmed/34620952 http://dx.doi.org/10.1038/s41598-021-99462-y |
| _version_ | 1784579995802271744 |
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| author | Natuzzi, Marco Grange, Coralie Gréa, Thomas Brichart, Thomas Aigle, Axel Bechet, Denise Hautefeuille, Benoit Thomas, Eloise Ayoub, Jean-Yves Bonnet, Jeanne-Marie Louzier, Vanessa Allaouchiche, Bernard Couturier, Aymeric Montembault, Alexandra de Oliveira, Paula Nunes David, Laurent Lux, François Tillement, Olivier |
| author_facet | Natuzzi, Marco Grange, Coralie Gréa, Thomas Brichart, Thomas Aigle, Axel Bechet, Denise Hautefeuille, Benoit Thomas, Eloise Ayoub, Jean-Yves Bonnet, Jeanne-Marie Louzier, Vanessa Allaouchiche, Bernard Couturier, Aymeric Montembault, Alexandra de Oliveira, Paula Nunes David, Laurent Lux, François Tillement, Olivier |
| author_sort | Natuzzi, Marco |
| collection | PubMed |
| description | In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals. |
| format | Online Article Text |
| id | pubmed-8497614 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84976142021-10-12 Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer Natuzzi, Marco Grange, Coralie Gréa, Thomas Brichart, Thomas Aigle, Axel Bechet, Denise Hautefeuille, Benoit Thomas, Eloise Ayoub, Jean-Yves Bonnet, Jeanne-Marie Louzier, Vanessa Allaouchiche, Bernard Couturier, Aymeric Montembault, Alexandra de Oliveira, Paula Nunes David, Laurent Lux, François Tillement, Olivier Sci Rep Article In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals. Nature Publishing Group UK 2021-10-07 /pmc/articles/PMC8497614/ /pubmed/34620952 http://dx.doi.org/10.1038/s41598-021-99462-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Natuzzi, Marco Grange, Coralie Gréa, Thomas Brichart, Thomas Aigle, Axel Bechet, Denise Hautefeuille, Benoit Thomas, Eloise Ayoub, Jean-Yves Bonnet, Jeanne-Marie Louzier, Vanessa Allaouchiche, Bernard Couturier, Aymeric Montembault, Alexandra de Oliveira, Paula Nunes David, Laurent Lux, François Tillement, Olivier Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title | Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title_full | Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title_fullStr | Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title_full_unstemmed | Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title_short | Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| title_sort | feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497614/ https://www.ncbi.nlm.nih.gov/pubmed/34620952 http://dx.doi.org/10.1038/s41598-021-99462-y |
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