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Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation

Background: Insomnia is a widespread problem that can lead to the occurrence of other diseases and correlates closely with sympathetic nerve hyperactivation. Obesity-induced hepatic steatosis is mediated by sympathetic overactivation. However, it remains unclear whether insomnia may cause hepatic st...

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Autores principales: Wang, Zongding, Liang, Xiaoyan, Lu, Yanmei, Jiang, Tiemin, Aji, Tuerganaili, Aimulajiang, Kalibixiati, Sun, Huaxin, Zhang, Ling, Zhou, Xianhui, Tang, Baopeng, Wen, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497715/
https://www.ncbi.nlm.nih.gov/pubmed/34630154
http://dx.doi.org/10.3389/fphys.2021.734009
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author Wang, Zongding
Liang, Xiaoyan
Lu, Yanmei
Jiang, Tiemin
Aji, Tuerganaili
Aimulajiang, Kalibixiati
Sun, Huaxin
Zhang, Ling
Zhou, Xianhui
Tang, Baopeng
Wen, Hao
author_facet Wang, Zongding
Liang, Xiaoyan
Lu, Yanmei
Jiang, Tiemin
Aji, Tuerganaili
Aimulajiang, Kalibixiati
Sun, Huaxin
Zhang, Ling
Zhou, Xianhui
Tang, Baopeng
Wen, Hao
author_sort Wang, Zongding
collection PubMed
description Background: Insomnia is a widespread problem that can lead to the occurrence of other diseases and correlates closely with sympathetic nerve hyperactivation. Obesity-induced hepatic steatosis is mediated by sympathetic overactivation. However, it remains unclear whether insomnia may cause hepatic steatosis. The goal of this study was to preliminarily investigate whether insomnia caused hepatic steatosis in rats via sympathetic hyperactivation. Methods: A total of 32 Sprague-Dawley male rats were divided randomly into four groups: model, sympathetic denervation (Sd), estazolam, and control (eight rats/group). Model group received sustained sleep deprivation using the modified multiple platform method. In the Sd group, rats underwent sleep deprivation after receiving Sd by 6-hydroxydopamine (6-OHDA). Estazolam group: the rats concurrently received sleep deprivation and treatment with estazolam. The other eight rats housed in cages and kept in a comfortable environment were used as control. Blood samples were obtained for analysis of plasma lipids and hepatic function. Sympathetic hyperactivation-related indexes and hepatic steatosis in liver tissues were tested. Results: Liver enzymes, plasma lipid levels, and hepatic steatosis were elevated in insomnia rats, and sympathetic hyperactivation was found. Insomnia-induced hepatic steatosis was effectively lowered with pharmacological ablation of the hepatic sympathetic nerves. Furthermore, the treatment of insomnia with estazolam inhibited sympathetic activation and reduced hepatic steatosis. Conclusion: Sustained sleep deprivation-induced insomnia promotes hepatic steatosis in rats possibly by mediating sympathetic overactivation.
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spelling pubmed-84977152021-10-09 Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation Wang, Zongding Liang, Xiaoyan Lu, Yanmei Jiang, Tiemin Aji, Tuerganaili Aimulajiang, Kalibixiati Sun, Huaxin Zhang, Ling Zhou, Xianhui Tang, Baopeng Wen, Hao Front Physiol Physiology Background: Insomnia is a widespread problem that can lead to the occurrence of other diseases and correlates closely with sympathetic nerve hyperactivation. Obesity-induced hepatic steatosis is mediated by sympathetic overactivation. However, it remains unclear whether insomnia may cause hepatic steatosis. The goal of this study was to preliminarily investigate whether insomnia caused hepatic steatosis in rats via sympathetic hyperactivation. Methods: A total of 32 Sprague-Dawley male rats were divided randomly into four groups: model, sympathetic denervation (Sd), estazolam, and control (eight rats/group). Model group received sustained sleep deprivation using the modified multiple platform method. In the Sd group, rats underwent sleep deprivation after receiving Sd by 6-hydroxydopamine (6-OHDA). Estazolam group: the rats concurrently received sleep deprivation and treatment with estazolam. The other eight rats housed in cages and kept in a comfortable environment were used as control. Blood samples were obtained for analysis of plasma lipids and hepatic function. Sympathetic hyperactivation-related indexes and hepatic steatosis in liver tissues were tested. Results: Liver enzymes, plasma lipid levels, and hepatic steatosis were elevated in insomnia rats, and sympathetic hyperactivation was found. Insomnia-induced hepatic steatosis was effectively lowered with pharmacological ablation of the hepatic sympathetic nerves. Furthermore, the treatment of insomnia with estazolam inhibited sympathetic activation and reduced hepatic steatosis. Conclusion: Sustained sleep deprivation-induced insomnia promotes hepatic steatosis in rats possibly by mediating sympathetic overactivation. Frontiers Media S.A. 2021-09-24 /pmc/articles/PMC8497715/ /pubmed/34630154 http://dx.doi.org/10.3389/fphys.2021.734009 Text en Copyright © 2021 Wang, Liang, Lu, Jiang, Aji, Aimulajiang, Sun, Zhang, Zhou, Tang and Wen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Zongding
Liang, Xiaoyan
Lu, Yanmei
Jiang, Tiemin
Aji, Tuerganaili
Aimulajiang, Kalibixiati
Sun, Huaxin
Zhang, Ling
Zhou, Xianhui
Tang, Baopeng
Wen, Hao
Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title_full Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title_fullStr Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title_full_unstemmed Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title_short Insomnia Promotes Hepatic Steatosis in Rats Possibly by Mediating Sympathetic Overactivation
title_sort insomnia promotes hepatic steatosis in rats possibly by mediating sympathetic overactivation
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497715/
https://www.ncbi.nlm.nih.gov/pubmed/34630154
http://dx.doi.org/10.3389/fphys.2021.734009
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