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Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis

An owner's ability to detect changes in the behavior of a dog afflicted with osteoarthritis (OA) may be a barrier to presentation, clinical diagnosis and initiation of treatment. Management of OA also relies upon an owner's ability to accurately monitor improvement following a trial period...

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Autores principales: Roberts, Claire, Armson, Bryony, Bartram, David, Belshaw, Zoe, Capon, Hannah, Cherry, Georgina, Gonzalez Villeta, Laura, McIntyre, Shona L., Odeyemi, Isaac, Cook, Alasdair J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497798/
https://www.ncbi.nlm.nih.gov/pubmed/34631862
http://dx.doi.org/10.3389/fvets.2021.741864
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author Roberts, Claire
Armson, Bryony
Bartram, David
Belshaw, Zoe
Capon, Hannah
Cherry, Georgina
Gonzalez Villeta, Laura
McIntyre, Shona L.
Odeyemi, Isaac
Cook, Alasdair J. C.
author_facet Roberts, Claire
Armson, Bryony
Bartram, David
Belshaw, Zoe
Capon, Hannah
Cherry, Georgina
Gonzalez Villeta, Laura
McIntyre, Shona L.
Odeyemi, Isaac
Cook, Alasdair J. C.
author_sort Roberts, Claire
collection PubMed
description An owner's ability to detect changes in the behavior of a dog afflicted with osteoarthritis (OA) may be a barrier to presentation, clinical diagnosis and initiation of treatment. Management of OA also relies upon an owner's ability to accurately monitor improvement following a trial period of pain relief. The changes in behavior that are associated with the onset and relief of pain from OA can be assessed to determine the dog's health-related quality of life (HRQOL). HRQOL assessments are widely used in human medicine and if developed correctly can be used in the monitoring of disease and in clinical trials. This study followed established guidelines to construct a conceptual framework of indicators of HRQOL in dogs with OA. This generated items that can be used to develop a HRQOL assessment tool specific to dogs with OA. A systematic review was conducted using Web of Science, PubMed and Scopus with search terms related to indicators of HRQOL in dogs with osteoarthritis. Eligibility and quality assessment criteria were applied. Data were extracted from eligible studies using a comprehensive data charting table. Resulting domains and items were assessed at a half-day workshop attended by experts in canine osteoarthritis and quality of life. Domains and their interactions were finalized and a visual representation of the conceptual framework was produced. A total of 1,264 unique articles were generated in the database searches and assessed for inclusion. Of these, 21 progressed to data extraction. After combining synonyms, 47 unique items were categorized across six domains. Review of the six domains by the expert panel resulted in their reduction to four: physical appearance, capability, behavior, and mood. All four categories were deemed to be influenced by pain from osteoarthritis. Capability, mood, and behavior were all hypothesized to impact on each other while physical appearance was impacted by, but did not impact upon, the other domains. The framework has potential application to inform the development of valid and reliable instruments to operationalize measurement of HRQOL in canine OA for use in general veterinary practice to guide OA management decisions and in clinical studies to evaluate treatment outcomes.
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spelling pubmed-84977982021-10-09 Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis Roberts, Claire Armson, Bryony Bartram, David Belshaw, Zoe Capon, Hannah Cherry, Georgina Gonzalez Villeta, Laura McIntyre, Shona L. Odeyemi, Isaac Cook, Alasdair J. C. Front Vet Sci Veterinary Science An owner's ability to detect changes in the behavior of a dog afflicted with osteoarthritis (OA) may be a barrier to presentation, clinical diagnosis and initiation of treatment. Management of OA also relies upon an owner's ability to accurately monitor improvement following a trial period of pain relief. The changes in behavior that are associated with the onset and relief of pain from OA can be assessed to determine the dog's health-related quality of life (HRQOL). HRQOL assessments are widely used in human medicine and if developed correctly can be used in the monitoring of disease and in clinical trials. This study followed established guidelines to construct a conceptual framework of indicators of HRQOL in dogs with OA. This generated items that can be used to develop a HRQOL assessment tool specific to dogs with OA. A systematic review was conducted using Web of Science, PubMed and Scopus with search terms related to indicators of HRQOL in dogs with osteoarthritis. Eligibility and quality assessment criteria were applied. Data were extracted from eligible studies using a comprehensive data charting table. Resulting domains and items were assessed at a half-day workshop attended by experts in canine osteoarthritis and quality of life. Domains and their interactions were finalized and a visual representation of the conceptual framework was produced. A total of 1,264 unique articles were generated in the database searches and assessed for inclusion. Of these, 21 progressed to data extraction. After combining synonyms, 47 unique items were categorized across six domains. Review of the six domains by the expert panel resulted in their reduction to four: physical appearance, capability, behavior, and mood. All four categories were deemed to be influenced by pain from osteoarthritis. Capability, mood, and behavior were all hypothesized to impact on each other while physical appearance was impacted by, but did not impact upon, the other domains. The framework has potential application to inform the development of valid and reliable instruments to operationalize measurement of HRQOL in canine OA for use in general veterinary practice to guide OA management decisions and in clinical studies to evaluate treatment outcomes. Frontiers Media S.A. 2021-09-24 /pmc/articles/PMC8497798/ /pubmed/34631862 http://dx.doi.org/10.3389/fvets.2021.741864 Text en Copyright © 2021 Roberts, Armson, Bartram, Belshaw, Capon, Cherry, Gonzalez Villeta, McIntyre, Odeyemi and Cook. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Roberts, Claire
Armson, Bryony
Bartram, David
Belshaw, Zoe
Capon, Hannah
Cherry, Georgina
Gonzalez Villeta, Laura
McIntyre, Shona L.
Odeyemi, Isaac
Cook, Alasdair J. C.
Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title_full Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title_fullStr Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title_full_unstemmed Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title_short Construction of a Conceptual Framework for Assessment of Health-Related Quality of Life in Dogs With Osteoarthritis
title_sort construction of a conceptual framework for assessment of health-related quality of life in dogs with osteoarthritis
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497798/
https://www.ncbi.nlm.nih.gov/pubmed/34631862
http://dx.doi.org/10.3389/fvets.2021.741864
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