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Artificial Sweeteners: History and New Concepts on Inflammation
Since the introduction of artificial sweeteners (AS) to the North American market in the 1950s, a growing number of epidemiological and animal studies have suggested that AS may induce changes in gut bacteria and gut wall immune reactivity, which could negatively affect individuals with or susceptib...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497813/ https://www.ncbi.nlm.nih.gov/pubmed/34631773 http://dx.doi.org/10.3389/fnut.2021.746247 |
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author | Basson, Abigail Raffner Rodriguez-Palacios, Alexander Cominelli, Fabio |
author_facet | Basson, Abigail Raffner Rodriguez-Palacios, Alexander Cominelli, Fabio |
author_sort | Basson, Abigail Raffner |
collection | PubMed |
description | Since the introduction of artificial sweeteners (AS) to the North American market in the 1950s, a growing number of epidemiological and animal studies have suggested that AS may induce changes in gut bacteria and gut wall immune reactivity, which could negatively affect individuals with or susceptible to chronic inflammatory conditions such as inflammatory bowel disease (IBD), a disorder that has been growing exponentially in westernized countries. This review summarizes the history of current FDA-approved AS and their chemical composition, metabolism, and bacterial utilization, and provides a scoping overview of the disease mechanisms associated with the induction or prevention of inflammation in IBD. We provide a general outlook on areas that have been both largely and scarcely studied, emerging concepts using silica, and describe the effects of AS on acute and chronic forms of intestinal inflammation. |
format | Online Article Text |
id | pubmed-8497813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84978132021-10-09 Artificial Sweeteners: History and New Concepts on Inflammation Basson, Abigail Raffner Rodriguez-Palacios, Alexander Cominelli, Fabio Front Nutr Nutrition Since the introduction of artificial sweeteners (AS) to the North American market in the 1950s, a growing number of epidemiological and animal studies have suggested that AS may induce changes in gut bacteria and gut wall immune reactivity, which could negatively affect individuals with or susceptible to chronic inflammatory conditions such as inflammatory bowel disease (IBD), a disorder that has been growing exponentially in westernized countries. This review summarizes the history of current FDA-approved AS and their chemical composition, metabolism, and bacterial utilization, and provides a scoping overview of the disease mechanisms associated with the induction or prevention of inflammation in IBD. We provide a general outlook on areas that have been both largely and scarcely studied, emerging concepts using silica, and describe the effects of AS on acute and chronic forms of intestinal inflammation. Frontiers Media S.A. 2021-09-24 /pmc/articles/PMC8497813/ /pubmed/34631773 http://dx.doi.org/10.3389/fnut.2021.746247 Text en Copyright © 2021 Basson, Rodriguez-Palacios and Cominelli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Basson, Abigail Raffner Rodriguez-Palacios, Alexander Cominelli, Fabio Artificial Sweeteners: History and New Concepts on Inflammation |
title | Artificial Sweeteners: History and New Concepts on Inflammation |
title_full | Artificial Sweeteners: History and New Concepts on Inflammation |
title_fullStr | Artificial Sweeteners: History and New Concepts on Inflammation |
title_full_unstemmed | Artificial Sweeteners: History and New Concepts on Inflammation |
title_short | Artificial Sweeteners: History and New Concepts on Inflammation |
title_sort | artificial sweeteners: history and new concepts on inflammation |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497813/ https://www.ncbi.nlm.nih.gov/pubmed/34631773 http://dx.doi.org/10.3389/fnut.2021.746247 |
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