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The Italian Version of the ALS Depression Inventory-12

Introduction: Depression is a comorbidity in patients with amyotrophic lateral sclerosis (ALS). However, its diagnosis is challenged by the co-occurrence of a similar frontotemporal (FT) behavioral symptom—i.e., apathy. Moreover, its psychometric evaluation is confounded by motor disabilities. This...

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Autores principales: Pain, Debora, Aiello, Edoardo Nicolò, Gallucci, Marcello, Miglioretti, Massimo, Mora, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497880/
https://www.ncbi.nlm.nih.gov/pubmed/34630298
http://dx.doi.org/10.3389/fneur.2021.723776
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author Pain, Debora
Aiello, Edoardo Nicolò
Gallucci, Marcello
Miglioretti, Massimo
Mora, Gabriele
author_facet Pain, Debora
Aiello, Edoardo Nicolò
Gallucci, Marcello
Miglioretti, Massimo
Mora, Gabriele
author_sort Pain, Debora
collection PubMed
description Introduction: Depression is a comorbidity in patients with amyotrophic lateral sclerosis (ALS). However, its diagnosis is challenged by the co-occurrence of a similar frontotemporal (FT) behavioral symptom—i.e., apathy. Moreover, its psychometric evaluation is confounded by motor disabilities. This study aimed at investigating psychometric properties and feasibility of the ALS Depression Inventory (ADI-12), a self-report questionnaire set up for this issue—as measuring mood changes without referring to movement. Methods: Eighty-five ALS patients were administered the ADI-12 and underwent cognitive (Mini-Mental State Examination, MMSE), quality of life (McGill Quality of Life Questionnaire, MQoL) and further anxiety/mood (Hospital Anxiety and Depression Scale, HADS) assessments. Reliability, validity, sensitivity, and specificity of the ADI-12 were explored. Results: Principal component analyses revealed two related components—“Negative Mood and Lack of Energy” (ME) and “Anhedonia” (A). Both components and the inventory as a whole were internally consistent and highly related to HADS-D. ADI-12-total score was also associated with HADS-A. ADI-12 measures were inversely related to MQoL. ADI-12-total/sub-scales were not related to either MMSE or disease-related outcomes. Estimates of depression yielded by HADS-D and ADI-12 were 11.1 and 35.3%. Discussion: The ADI-12 is a valid, reliable and usable feasibile tool to assess depression in Italian ALS patients independently from motor disabilities. Its interplay with psycho-social outcomes is in agreement with previous studies. The lack of association with cognition suggests that the ADI-12 is partially independent from FT spectrum disorders. The disagreement in depression rates between the ADI-12 and HADS-D suggests the need to ALS-specific mood scales.
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spelling pubmed-84978802021-10-09 The Italian Version of the ALS Depression Inventory-12 Pain, Debora Aiello, Edoardo Nicolò Gallucci, Marcello Miglioretti, Massimo Mora, Gabriele Front Neurol Neurology Introduction: Depression is a comorbidity in patients with amyotrophic lateral sclerosis (ALS). However, its diagnosis is challenged by the co-occurrence of a similar frontotemporal (FT) behavioral symptom—i.e., apathy. Moreover, its psychometric evaluation is confounded by motor disabilities. This study aimed at investigating psychometric properties and feasibility of the ALS Depression Inventory (ADI-12), a self-report questionnaire set up for this issue—as measuring mood changes without referring to movement. Methods: Eighty-five ALS patients were administered the ADI-12 and underwent cognitive (Mini-Mental State Examination, MMSE), quality of life (McGill Quality of Life Questionnaire, MQoL) and further anxiety/mood (Hospital Anxiety and Depression Scale, HADS) assessments. Reliability, validity, sensitivity, and specificity of the ADI-12 were explored. Results: Principal component analyses revealed two related components—“Negative Mood and Lack of Energy” (ME) and “Anhedonia” (A). Both components and the inventory as a whole were internally consistent and highly related to HADS-D. ADI-12-total score was also associated with HADS-A. ADI-12 measures were inversely related to MQoL. ADI-12-total/sub-scales were not related to either MMSE or disease-related outcomes. Estimates of depression yielded by HADS-D and ADI-12 were 11.1 and 35.3%. Discussion: The ADI-12 is a valid, reliable and usable feasibile tool to assess depression in Italian ALS patients independently from motor disabilities. Its interplay with psycho-social outcomes is in agreement with previous studies. The lack of association with cognition suggests that the ADI-12 is partially independent from FT spectrum disorders. The disagreement in depression rates between the ADI-12 and HADS-D suggests the need to ALS-specific mood scales. Frontiers Media S.A. 2021-09-24 /pmc/articles/PMC8497880/ /pubmed/34630298 http://dx.doi.org/10.3389/fneur.2021.723776 Text en Copyright © 2021 Pain, Aiello, Gallucci, Miglioretti and Mora. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Pain, Debora
Aiello, Edoardo Nicolò
Gallucci, Marcello
Miglioretti, Massimo
Mora, Gabriele
The Italian Version of the ALS Depression Inventory-12
title The Italian Version of the ALS Depression Inventory-12
title_full The Italian Version of the ALS Depression Inventory-12
title_fullStr The Italian Version of the ALS Depression Inventory-12
title_full_unstemmed The Italian Version of the ALS Depression Inventory-12
title_short The Italian Version of the ALS Depression Inventory-12
title_sort italian version of the als depression inventory-12
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497880/
https://www.ncbi.nlm.nih.gov/pubmed/34630298
http://dx.doi.org/10.3389/fneur.2021.723776
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